Decoding molecular and cellular heterogeneity of mouse nucleus accumbens.
Decoding molecular and cellular heterogeneity of mouse nucleus accumbens.
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DOI：
10.1038/s41593-021-00938-x
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发表时间：
2021-12
影响因子：
25
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Chen R;Blosser TR;Djekidel MN;Hao J;Bhattacherjee A;Chen W;Tuesta LM;Zhuang X;Zhang Y
The nucleus accumbens (NAc) plays an important role in regulating multiple behaviors, and its dysfunction has been linked to many neural disorders. However, the molecular, cellular and anatomic heterogeneity underlying its functional diversity remains incompletely understood. In this study, we generated a cell census of the mouse NAc using single-cell RNA sequencing and multiplexed error-robust fluorescence in situ hybridization, revealing a high level of cell heterogeneity in this brain region. Here we show that the transcriptional and spatial diversity of neuron subtypes underlie the NAc’s anatomic and functional heterogeneity. These findings explain how the seemingly simple neuronal composition of the NAc achieves its highly heterogenous structure and diverse functions. Collectively, our study generates a spatially resolved cell taxonomy for understanding the structure and function of the NAc, which demonstrates the importance of combining molecular and spatial information in revealing the fundamental features of the nervous system.
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影响因子：
5.8
作者：
Gu, Zuguang;Eils, Roland;Schlesner, Matthias
通讯作者：
Schlesner, Matthias
影响因子：
16.2
作者：
Banghart MR;Neufeld SQ;Wong NC;Sabatini BL
通讯作者：
Sabatini BL
DOI：
10.1038/npp.2009.187
发表时间：
2010-02
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
14.8
作者：
Brewer, Gregory J.;Torricelli, John R.
通讯作者：
Torricelli, John R.
影响因子：
25
作者：
Ito, R;Robbins, TW;Everitt, BJ
通讯作者：
Everitt, BJ