Separable roles of the nucleus accumbens core and shell in context- and cue-induced alcohol-seeking.
Separable roles of the nucleus accumbens core and shell in context- and cue-induced alcohol-seeking.
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DOI：
10.1038/npp.2009.187
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发表时间：
2010-02
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影响因子：
--
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药物预测的离散线索的条件反应可以强烈调制药物相关的背景。我们测试了这一假设，即差异招聘的核神经元的核心和外壳介导的药物与非药物背景下的药物线索的反应。大鼠被训练区分两种10秒的听觉刺激：一种刺激（CS+）与乙醇（10%v/v; 0.2ml;口服）配对，而另一种刺激（CS-）则没有。训练发生在操作性条件反射室区分的上下文刺激，并导致增加进入乙醇输送端口在CS+相比，CS-。在实验1中，端口条目，然后熄灭在第二个上下文中扣留乙醇，之后上下文诱导的更新乙醇寻求进行了测试，提出两个刺激，没有乙醇在先前的培训背景。这种操作刺激了在核心（n=9）或外壳（n=10）中用盐水预处理的大鼠对CS+的强烈反应，这在试验前通过使任一亚区失活（蝇蕈醇/巴氯芬; 0.1/1.0 mM; 0.3μl/侧）而减弱。在实验2中，以下歧视训练大鼠习惯于不同的情况下，乙醇和两种刺激被扣留。线索诱导的乙醇寻求，然后引发了CS+和CS-在不同的情况下，没有乙醇。生理盐水预处理的大鼠对CS+的反应比CS-的反应更大（核心n=8;外壳n=9），灭活核心而不是外壳减弱了这种效应。这些数据突出了线索诱导乙醇寻求的核心的重要作用，并建议，壳需要调解的影响，条件乙醇寻求的背景。
Conditioned responding to drug-predictive discrete cues can be strongly modulated by drug-associated contexts. We tested the hypothesis that differential recruitment of the nucleus accumbens core and shell mediates responding to drug cues in a drug versus non-drug context. Rats were trained to discriminate between two, 10-sec auditory stimuli: one stimulus (CS+) was paired with ethanol (10% v/v; 0.2ml; oral) while the other (CS−) was not. Training occurred in operant conditioning chambers distinguished by contextual stimuli, and resulted in increased entries into the ethanol delivery port during the CS+ compared to the CS−. In Experiment 1, port-entries were then extinguished in a second context by withholding ethanol, after which context-induced renewal of ethanol-seeking was tested by presenting both stimuli without ethanol in the prior training context. This manipulation stimulated strong responding to the CS+ in rats pretreated with saline in the core (n=9) or shell (n=10), which was attenuated by pharmacologically inactivating (muscimol/baclofen; 0.1/1.0 mM; 0.3μl/side) either subregion pretest. In Experiment 2, following discrimination training rats were habituated to a different context where ethanol and both stimuli were withheld. Cue-induced ethanol-seeking was then elicited by presenting the CS+ and CS− without ethanol in the different context. Saline pretreated rats responded more to the CS+ than the CS− (core n=8; shell n=9), and inactivating the core but not shell attenuated this effect. These data highlight an important role for the core in cue-induced ethanol-seeking, and suggest that the shell is required to mediate the influence of contexts on conditioned ethanol-seeking.
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DOI：
10.1111/j.1460-9568.2008.06517.x
发表时间：
2008-12
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Chaudhri N;Sahuque LL;Cone JJ;Janak PH
通讯作者：
Janak PH
影响因子：
5.3
作者：
Floresco, SB;Ghods-Sharifi, S;Magyar, O
通讯作者：
Magyar, O
DOI：
10.1111/j.1530-0277.1999.tb04070.x
发表时间：
1999-11-01
影响因子：
3.2
作者：
Katner, SN;Weiss, F
通讯作者：
Weiss, F
影响因子：
25
作者：
Ito, R;Robbins, TW;Everitt, BJ
通讯作者：
Everitt, BJ
影响因子：
2.3
作者：
Conklin, CA
通讯作者：
Conklin, CA