HomeoboxC6 promotes metastasis by orchestrating the DKK1/Wnt/β-catenin axis in right-sided colon cancer.
HomeoboxC6 promotes metastasis by orchestrating the DKK1/Wnt/β-catenin axis in right-sided colon cancer.
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HomeoboxC6 通过协调右侧结肠癌中的 DKK1/Wnt/β-catenin 轴来促进转移
DOI：
10.1038/s41419-021-03630-x
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发表时间：
2021-04-01
影响因子：
9
通讯作者：
Hu W
中科院分区：
文献类型：
--
作者：
Qi L;Chen J;Zhou B;Xu K;Wang K;Fang Z;Shao Y;Yuan Y;Zheng S;Hu W
右侧结肠癌（RCC）患者的预后通常比左侧结肠癌（LCC）患者差。我们以前发现，同源异型盒C6（HOXC 6）是最显着上调基因在RCC相比，LCC。然而，目前尚不清楚HOXC 6是否在肿瘤增殖和转移中发挥作用。本研究旨在探讨HOXC 6在肾细胞癌中的潜在致癌作用及其分子机制。在这项研究中，HOXC 6被证实在RCC中过表达，并与预后不良相关。此外，HOXC 6的过表达通过激活Wnt/β-catenin信号通路诱导EMT，抑制DKK 1的分泌，促进结肠癌细胞的迁移和侵袭。最后，我们初步探索了HOXC 6的翻译作用，发现HOXC 6的沉默使HCT 116和HT 29细胞对伊立替康更敏感。
Patients with right-sided colon cancer (RCC) generally have a poorer prognosis than those with left-sided colon cancer (LCC). We previously found that homeobox C6 (HOXC6) was the most significantly upregulated gene in RCC compared to LCC. However, it remains unclear whether HOXC6 plays a role in tumor proliferation and metastasis. Our study aimed to explore the potential oncogenic role and the detailed molecular mechanism of HOXC6 in RCC. In this study, HOXC6 was validated to be overexpressed in RCC and associated with poor prognosis. Furthermore, overexpression of HOXC6 promoted the migration and invasion of colon cancer cells through inducing EMT by activating the Wnt/β-catenin signaling pathway and inhibition of DKK1 secretion. Lastly, we preliminary explored the translational effect of HOXC6 and found that silencing of HOXC6 made HCT116 and HT29 cells more sensitive to irinotecan.
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