Emerging drugs for osteoarthritis.
Emerging drugs for osteoarthritis.
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DOI：
10.1517/14728214.2011.576670
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发表时间：
2011-09
影响因子：
3.4
通讯作者：
Hunter DJ
中科院分区：
文献类型：
--
作者：
Matthews GL;Hunter DJ
骨关节炎（OA）是最常见的关节疾病，影响世界人口的13%。在美国，它是65岁以上人群残疾的主要原因，其特征在于进行性软骨损失、骨重塑、骨赘形成和滑膜炎症，导致关节疼痛和残疾。目前还没有针对结构性疾病改变的治疗方法上市;目前的治疗方法主要针对症状，>75%的患者报告需要额外的对症治疗。药物在以后的发展（阶段II-III）骨关节炎疼痛和关节结构退化的审查。不包括基于程序（例如关节穿刺术、物理治疗）、行为（例如减肥、疼痛应对技术）或器械（例如膝关节支架、外科植入物）的治疗。更深入地了解疾病的病理生理学，以及阐明临床关节病学与关节结构变化之间的联系，可能会导致未来开发具有良好疗效的新靶点类别。尽管有效，但在这些治疗剂的临床开发中仍然存在重大障碍需要克服，这些障碍是疾病进展模式所固有的，以及疼痛和结构修饰试验的读数挑战。
Osteoarthritis (OA), the most prevalent form of joint disease, affecting as much as 13% of the world’s population. In the United States, it is the leading cause of disability in people over age 65 and is characterized by progressive cartilage loss, bone remodeling, osteophyte formation and synovial inflammation with resultant joint pain and disability. There are no treatments marketed for structural disease modification; current treatments mainly target symptoms, with >75% of patients reporting need for additional symptomatic treatment. Drugs in later development (Phase II-III) for osteoarthritis pain and joint structural degeneration are reviewed. Not covered are procedural (e.g. arthrocentesis, physical therapy), behavioral (e.g. weight loss, pain coping techniques) or device (e.g. knee braces, surgical implants) based treatments. More in depth understanding of the pathophysiology of the disease, as well as elucidation of the link between clinical symptomatology and structural changes in the joint will likely lead to development of novel target classes with promising efficacy in the future. Efficacy notwithstanding, there remain significant hurdles to overcome in clinical development of these therapeutics, inherent in the progression pattern of the disease as well as challenges with readouts for both pain and structure modification trials.
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影响因子：
--
作者：
Elshaier, Arriel M.;Hakimiyan, Arnavaz A.;Rappoport, Lev;Rueger, David C.;Chubinskaya, Susan
通讯作者：
Chubinskaya, Susan
影响因子：
64.8
作者：
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通讯作者：
Julius, D
影响因子：
7
作者：
Ellsworth, JL;Berry, J;Hughes, SD
通讯作者：
Hughes, SD
影响因子：
9
作者：
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通讯作者：
Büchler, MW
影响因子：
16.2
作者：
Cesare, P;Dekker, LV;McNaughton, PA
通讯作者：
McNaughton, PA