The effect of 0.5% tropicamide/0.5% phenylephrine mixed eye drop in Chinese adults with myopia and its inter-eye difference in refractive outcomes
The effect of 0.5% tropicamide/0.5% phenylephrine mixed eye drop in Chinese adults with myopia and its inter-eye difference in refractive outcomes
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%20效果%20of%200.5%%20托吡卡胺/0.5%%20去氧肾上腺素%20混合%20眼%20滴%20in%20中国人%20成人%20与%20近视%20和%20其%20眼间%20差异%20in%20屈光%20结果
DOI：
10.1185/03007995.2013.861348
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发表时间：
2014
影响因子：
2.3
通讯作者：
Yi Lu
中科院分区：
文献类型：
--
作者：
Xiangjia Zhu;Min;J. Dai;Yi Lu
摘要目的：目的评价0.5%托吡卡胺/0.5%苯吡酮混合滴眼液治疗中国成人近视的疗效，并进行屈光状态的眼间比较。研究方法：对341例近视眼患者在不使用睫状肌麻痹剂的情况下进行屈光检查，30分钟后用0.5%托吡卡胺/0.5%苯异丙胺混合滴眼液（Mydrin-P）重复检查。向量分析用于分析数据。这两次屈光之间J 0和J 45分量的等效球镜（M）和散光变化计算为Error_M、Error_J0和Error_J45。研究了眼间相关性。睫状肌麻痹剂后的眼间差异被描述为Diff M、Diff J 0和Diff J 45。分析屈光参差、年龄和高阶像差对睫状肌麻痹剂眼间差异的影响。结果：两只眼睛之间仅Error_J45分量存在差异（p = 0.0040）。对于Error_M、Error_J0和Error_J45，双眼之间的Pearson相关系数分别为0.3140（p < 0.0001）、0.1464（p = 0.0068）和0.0099（p = 0.8558）。对睫状肌麻痹剂反应的眼间差异（Diff）随屈光参差程度的增加而增加。年龄最大的组具有最高的Diff M值。然而，HOA被发现与眼间差异无关。结论：托吡卡胺/苯异丙胺滴眼液对近视眼的调节仍有松弛作用。近视患者因睫状肌麻痹而引起的屈光变化在双眼之间没有很好的相关性。屈光参差和眼优势可能是造成眼间差异的重要因素。
Abstract Objective: To evaluate the effect of 0.5% tropicamide/0.5% phenylephrine mixed eye drop and make the inter-eye comparison of refractive outcomes in Chinese adults with myopia. Methods: Refractive measurements were performed without cycloplegia and repeated 30 minutes later with 0.5% tropicamide/0.5% phenylephrine mixed eye drop (Mydrin-P) on 341 myopic adults. Vector analysis was used to analyze the data. Changes of spherical equivalent (M) and astigmatism for both J0 and J45 components between these two refractions were calculated as Error_M, Error_J0 and Error_J45. Inter-eye correlations were studied. The inter-eye difference after cycloplegics were described as Diff M, Diff J0 and Diff J45. The effect of anisometropia, age and the higher order aberrations (HOAs) on inter-eye differences toward the cycloplegic agent were analyzed. Results: Difference was found only for the Error_J45 component between the two eyes (p = 0.0040). Pearson correlation coefficients between the two eyes for Error_M, Error_J0, and Error_J45 were 0.3140 (p < 0.0001), 0.1464 (p = 0.0068), and 0.0099 (p = 0.8558), respectively. The inter-eye differences (Diff) in response to cycloplegic agent increased with the amount of anisometropia. The oldest group had the highest Diff M values. However, HOAs were found not to be related to the inter-eye differences. Conclusions: Accommodation was still relaxed by tropicamide/phenylephrine eye drops in myopic adults. The changes of refraction due to cycloplegia were not well correlated between the two eyes in myopic patients. Anisometropia and ocular dominance might be an important factor for the inter-eye difference.
影响因子：
2.4
作者：
Hamasaki, Ichiro;Hasebe, Satoshi;Ohtsuki, Hiroshi
通讯作者：
Ohtsuki, Hiroshi