Supply chain logistics - the role of the Golgi complex in extracellular matrix production and maintenance.
Supply chain logistics - the role of the Golgi complex in extracellular matrix production and maintenance.
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DOI：
10.1242/jcs.258879
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发表时间：
2022-01-01
影响因子：
4
通讯作者：
Lowe M
中科院分区：
文献类型：
--
作者：
Hellicar J;Stevenson NL;Stephens DJ;Lowe M
结缔组织的生物力学和生化特性是由其细胞外基质的组成和质量决定的。这反过来又高度依赖于分泌途径的功能和组织。高尔基复合体通过协调基质成分在分泌前的翻译后修饰和蛋白水解加工，在指导基质输出中起着至关重要的作用。这些修饰对基质成分的分泌和随后的组装以及它们在细胞外环境中的功能有广泛的影响。在这篇综述中，我们重点介绍了高尔基体在形成适应性强的健康基质中的作用，并以蛋白聚糖和前胶原分泌为例。然后我们讨论在人类疾病和衰老的背景下高尔基体功能障碍对结缔组织的影响。摘要：本文综述了目前对高尔基体（分泌途径的中心细胞器）在细胞外基质的产生和维持中的主要作用的了解。
The biomechanical and biochemical properties of connective tissues are determined by the composition and quality of their extracellular matrix. This, in turn, is highly dependent on the function and organisation of the secretory pathway. The Golgi complex plays a vital role in directing matrix output by co-ordinating the post-translational modification and proteolytic processing of matrix components prior to their secretion. These modifications have broad impacts on the secretion and subsequent assembly of matrix components, as well as their function in the extracellular environment. In this Review, we highlight the role of the Golgi in the formation of an adaptable, healthy matrix, with a focus on proteoglycan and procollagen secretion as example cargoes. We then discuss the impact of Golgi dysfunction on connective tissue in the context of human disease and ageing. Summary: This Review describes current knowledge on the major role of the Golgi apparatus, the central organelle of the secretory pathway, in the production and maintenance of the extracellular matrix.
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