Noninvasive estimation of local speed of sound by pulse-echo ultrasound in a rat model of nonalcoholic fatty liver.
Noninvasive estimation of local speed of sound by pulse-echo ultrasound in a rat model of nonalcoholic fatty liver.
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DOI：
10.1088/1361-6560/ac4562
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发表时间：
2022-01-17
影响因子：
3.5
通讯作者：
Dahl JJ
中科院分区：
文献类型：
--
作者：
Telichko AV;Ali R;Brevett T;Wang H;Vilches-Moure JG;Kumar SU;Paulmurugan R;Dahl JJ
先前已经证明声速与肝脏中的脂肪浓度相关。然而，非侵入性地估计肝脏中的声速可能被覆盖肝脏的组织层的声速所偏置。在这里，我们展示了一个非侵入性的本地声速估计，这是基于分层介质的假设，可以准确地捕捉到肝脏中的声速。我们使用肥胖Zucker大鼠非酒精性脂肪性肝病模型验证估计量，并将局部声速与肝脏脂肪变性相关联。我们估计当地和全球的平均声速非侵入性4瘦Zucker大鼠喂养正常饮食和16肥胖Zucker大鼠喂养高脂肪饮食长达8周。使用已建立的技术从切除的肝脏测量声音的地面真实速度和脂肪浓度。肝脏的无创局部声速估计值与其相应的“地面实况”测量值相似，斜率±回归标准误为0.82 ± 0.15（R2 = 0.74，p < 0.001）。无创性全局平均声速的测量不能可靠地捕获肝脏中的“地面真实”声速，斜率为0.35±0.07（R2 = 0.74和p < 0.001）。随着肝脏脂肪堆积的增加（肝脏脂肪每增加1%，局部声速约为-1.7 m/s）和组织病理学脂肪变性分级（脂肪变性等级每增加1个单位，局部声速约为-10至-13 m/s），观察到局部声速降低。局部声速估计值与脂肪变性等级高度相关，Pearson和斯皮尔曼相关系数范围均为-0.87至-0.78。此外，通过离体测量观察到肝脏中的叶依赖性声速，在同一动物的肝脏中的叶之间观察到高达25 m/s（p < 0.003）的声速差异。这项研究的结果表明，局部声速估计有可能被用来预测或协助测量肝脏脂肪浓度和全球平均声速应避免在肝脏脂肪估计由于显着的偏见，在声速估计。
Speed of sound has previously been demonstrated to correlate with fat concentration in the liver. However, estimating speed of sound in the liver noninvasively can be biased by the speed of sound of the tissue layers overlying the liver. Here, we demonstrate a noninvasive local speed of sound estimator, which is based on a layered media assumption, that can accurately capture the speed of sound in the liver. We validate the estimator using an obese Zucker rat model of non-alcoholic fatty liver disease and correlate the local speed of sound with liver steatosis. We estimated the local and global average speed of sound noninvasively in 4 lean Zucker rats fed a normal diet and 16 obese Zucker rats fed a high fat diet for up to 8 weeks. The ground truth speed of sound and fat concentration were measured from the excised liver using established techniques. The noninvasive, local speed of sound estimates of the livers were similar in value to their corresponding “ground truth” measurements, having a slope ± standard error of the regression of 0.82 ± 0.15 (R2 = 0.74 and p < 0.001). Measurement of the noninvasive global average speed of sound did not reliably capture the “ground truth” speed of sound in the liver, having a slope of 0.35±0.07 (R2 = 0.74 and p < 0.001). Decreasing local speed of sound was observed with increasing hepatic fat accumulation (approximately −1.7 m/s per 1% increase in hepatic fat) and histopathology steatosis grading (approximately −10 to −13 m/s per unit increase in steatosis grade). Local speed of sound estimates were highly correlated with steatosis grade, having Pearson and Spearman correlation coefficients both ranging from −0.87 to −0.78. In addition, a lobe-dependent speed of sound in the liver was observed by the ex vivo measurements, with speed of sound differences of up to 25 m/s (p < 0.003) observed between lobes in the liver of the same animal. The findings of this study suggest that local speed of sound estimation has the potential to be used to predict or assist in the measurement of hepatic fat concentration and that the global average speed of sound should be avoided in hepatic fat estimation due to significant bias in the speed of sound estimate.
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DOI：
10.1109/tuffc.2017.2773495
发表时间：
2018-01
期刊：
IEEE transactions on ultrasonics, ferroelectrics, and frequency control
影响因子：
--
作者：
Bottenus N
通讯作者：
Bottenus N
影响因子：
19.7
作者：
Barr, Richard G.;Ferraioli, Giovanna;Levine, Deborah
通讯作者：
Levine, Deborah
影响因子：
6.2
作者：
Cheng, Yu-Fan;Yu, Chun-Yen;Chen, Chao-Long
通讯作者：
Chen, Chao-Long
DOI：
10.1109/tuffc.2019.2961875
发表时间：
2020-05-01
影响因子：
3.6
作者：
Ali, Rehman;Herickhoff, Carl D.;Bottenus, Nick
通讯作者：
Bottenus, Nick
影响因子：
10.6
作者：
Brickson LL;Hyun D;Jakovljevic M;Dahl JJ
通讯作者：
Dahl JJ