The Mass General Brigham Biobank Portal: an i2b2-based data repository linking disparate and high-dimensional patient data to support multimodal analytics.
The Mass General Brigham Biobank Portal: an i2b2-based data repository linking disparate and high-dimensional patient data to support multimodal analytics.
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群众杨百卫生物银行门户网站：基于I2B2的数据存储库，将不同和高维患者数据连接起来，以支持多模式分析。
DOI：
10.1093/jamia/ocab264
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发表时间：
2022-03-15
期刊：
影响因子：
--
通讯作者：
Murphy SN
中科院分区：
文献类型：
--
作者：
Castro VM;Gainer V;Wattanasin N;Benoit B;Cagan A;Ghosh B;Goryachev S;Metta R;Park H;Wang D;Mendis M;Rees M;Herrick C;Murphy SN
Integrating and harmonizing disparate patient data sources into one consolidated data portal enables researchers to conduct analysis efficiently and effectively. We describe an implementation of Informatics for Integrating Biology and the Bedside (i2b2) to create the Mass General Brigham (MGB) Biobank Portal data repository. The repository integrates data from primary and curated data sources and is updated weekly. The data are made readily available to investigators in a data portal where they can easily construct and export customized datasets for analysis. As of July 2021, there are 125 645 consented patients enrolled in the MGB Biobank. 88 527 (70.5%) have a biospecimen, 55 121 (43.9%) have completed the health information survey, 43 552 (34.7%) have genomic data and 124 760 (99.3%) have EHR data. Twenty machine learning computed phenotypes are calculated on a weekly basis. There are currently 1220 active investigators who have run 58 793 patient queries and exported 10 257 analysis files. The Biobank Portal allows noninformatics researchers to conduct study feasibility by querying across many data sources and then extract data that are most useful to them for clinical studies. While institutions require substantial informatics resources to establish and maintain integrated data repositories, they yield significant research value to a wide range of investigators. The Biobank Portal and other patient data portals that integrate complex and simple datasets enable diverse research use cases. i2b2 tools to implement these registries and make the data interoperable are open source and freely available.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
DOI：
10.1056/nejmsr1809937
发表时间：
2019-08-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
All of Us Research Program Investigators;Denny JC;Rutter JL;Goldstein DB;Philippakis A;Smoller JW;Jenkins G;Dishman E
通讯作者：
Dishman E
影响因子：
4.6
作者：
Chu SH;Wan ES;Cho MH;Goryachev S;Gainer V;Linneman J;Scotty EJ;Hebbring SJ;Murphy S;Lasky-Su J;Weiss ST;Smoller JW;Karlson E
通讯作者：
Karlson E
影响因子：
10.6
作者：
McCoy TH Jr;Castro VM;Hart KL;Pellegrini AM;Yu S;Cai T;Perlis RH
通讯作者：
Perlis RH
影响因子：
2.1
作者：
Bian, Jiang;Loiacono, Alexander;Hogan, William
通讯作者：
Hogan, William