Do patients with weight loss have a worse outcome when undergoing chemotherapy for lung cancers?
Do patients with weight loss have a worse outcome when undergoing chemotherapy for lung cancers?
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DOI：
10.1038/sj.bjc.6601781
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发表时间：
2004-05-17
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
研究就诊时体重减轻是否影响肺癌或间皮瘤化疗患者的预后。1994-2001年前瞻性收集数据的多变量分析。可获得年龄、性别、体能状态、组织学、分期、缓解、毒性、无进展和总生存期的数据。比较了小细胞肺癌（SCLC; n=290）、III期和IV期非小细胞肺癌（NSCLC; n=418）或间皮瘤（n=72）化疗后体重减轻或未减轻患者的结局。分别有59%、58%和76%的SCLC、NSCLC和间皮瘤患者报告体重减轻。体重减轻和NSCLC（P=0.003）或间皮瘤（P=0.05）的患者更经常未能完成至少三个周期的化疗。贫血作为毒性在体重减轻的NSCLC患者中发生率显著更高（P=0.0003）。其他毒性的发生率不受体重减轻的显著影响。体重减轻的NSCLC患者的症状缓解较少（P=0.001）。间皮瘤患者体重减轻的症状（P=0.03）和客观反应（P=0.05）较少。体重减轻是SCLC（P=0.003，相对风险（RR）=1.5）、NSCLC（P=0.009，RR=1.33）和间皮瘤（P=0.03，RR=1.92）患者总生存期较短的独立预测因素，也是SCLC患者无进展生存期的独立预测因素（P=0.01，RR=1.43）。总之，体重减轻作为肺癌的一种症状，预示着治疗的毒性和较短的生存期。
To examine whether weight loss at presentation influences outcome in patients who received chemotherapy for lung cancer or mesothelioma. Multivariate analysis of prospectively collected data 1994–2001. Data were available for age, gender, performance status, histology, stage, response, toxicity, progression-free and overall survival. The outcomes of patients with or without weight loss treated with chemotherapy for small cell lung cancer (SCLC; n=290), stages III and IV non-small-cell lung cancer (NSCLC; n=418), or mesothelioma (n=72) were compared. Weight loss was reported by 59, 58 and 76% of patients with SCLC, NSCLC and mesothelioma, respectively. Patients with weight loss and NSCLC (P=0.003) or mesothelioma (P=0.05) more frequently failed to complete at least three cycles of chemotherapy. Anaemia as a toxicity occurred significantly more frequently in NSCLC patients with weight loss (P=0.0003). The incidence of other toxicities was not significantly affected by weight loss. NSCLC patients with weight loss had fewer symptomatic responses (P=0.001). Mesothelioma patients with weight loss had fewer symptomatic (P=0.03) and objective responses (P=0.05). Weight loss was an independent predictor of shorter overall survival for patients with SCLC (P=0.003, relative risk (RR)=1.5), NSCLC (P=0.009, RR=1.33) and mesothelioma (P=0.03, RR=1.92) and an independent predictor of progression-free survival in patients with SCLC (P=0.01, RR=1.43). In conclusion, weight loss as a symptom of lung cancer predicts for toxicity from treatment and shorter survival.
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影响因子：
10
作者：
Edwards, JG;Abrams, KR;O'Byrne, KJ
通讯作者：
O'Byrne, KJ
DOI：
10.1097/00000421-199910000-00006
发表时间：
1999-10-01
影响因子：
2.6
作者：
Martins, SJ;Pereira, JR
通讯作者：
Pereira, JR
影响因子：
45.3
作者：
OVESEN, L;ALLINGSTRUP, L;HANSEN, OP
通讯作者：
HANSEN, OP
影响因子：
3.7
作者：
KAPLAN, EL;MEIER, P
通讯作者：
MEIER, P
影响因子：
8.8
作者：
Hickish, TF;Smith, IE;O'Brien, MER
通讯作者：
O'Brien, MER