Menthol cigarette smoking in the COPDGene cohort: relationship with COPD, comorbidities and CT metrics.
Menthol cigarette smoking in the COPDGene cohort: relationship with COPD, comorbidities and CT metrics.
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DOI：
10.1111/resp.12421
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Bowler RP
中科院分区：
文献类型：
--
作者：
Park SJ;Foreman MG;Demeo DL;Bhatt SP;Hansel NN;Wise RA;Soler X;Bowler RP
薄荷香烟含有较高水平的薄荷醇，可以产生一种独特的薄荷味和清凉感。与非薄荷卷烟相比，关于薄荷卷烟对慢性阻塞性肺疾病（COPD）临床和影像学特征影响的信息很少。本研究的主要目的是研究薄荷香烟的使用与慢性阻塞性肺病风险及其特征（如加重、合并症和计算机断层扫描（CT）异常）之间的关系。我们分析了COPDGene队列中5699名当前吸烟者的数据，以评估薄荷醇吸烟者和非薄荷醇吸烟者的肺功能、合并症、恶化和CT参数是否存在差异。有3758人（65.9%）报告使用薄荷香烟。多变量回归分析显示，年轻年龄、女性性别和非裔美国人种族与薄荷卷烟的吸烟显著相关。薄荷卷烟的使用与慢性阻塞性肺病、主要CT表现或合并症（如心血管疾病、充血性心力衰竭、周围血管疾病、脑血管疾病、高血压、糖尿病、胃食管反流和骨质疏松症）无显著相关性；然而，在纵向随访中，与不吸薄荷醇香烟的人相比，吸薄荷醇香烟的人更有可能经历COPD的严重恶化（优势比1.29；95%可信区间：1.01-1.54）。这些结果证实，薄荷卷烟并不比传统卷烟更安全，并表明薄荷卷烟吸烟者可能比非薄荷卷烟吸烟者更频繁地出现严重恶化。
Menthol cigarettes contain higher levels of menthol to produce a characteristic mint flavour and cooling sensation. Compared with non-menthol cigarettes, little information exists on the effects of menthol cigarette smoking on clinical and radiological characteristics of chronic obstructive pulmonary disease (COPD). The main objective of the present study was to examine associations between menthol cigarette use and the risk of COPD and its characteristics, such as exacerbation, comorbidities and computed tomography (CT) abnormalities. We analysed the data from 5699 current smokers in the COPDGene cohort to evaluate whether lung function, comorbidities, exacerbations and CT parameters were different between menthol and non-menthol cigarette smokers. There were 3758 (65.9%) who reported use of menthol cigarettes. Multivariable regression analysis revealed that younger age, female gender and African-American ethnicity were significantly associated with smoking of menthol cigarettes. No significant associations were found between menthol cigarette use and COPD, major CT findings or comorbidities, such as cardiovascular disease, congestive heart failure, peripheral vascular disease, cerebrovascular disease, hypertension, diabetes, gastro-oesophageal reflux and osteoporosis; however, menthol cigarette smokers were more likely to experience a severe exacerbation of COPD during longitudinal follow-up (odds ratio 1.29; 95% confidence interval: 1.01–1.54) compared with the non-menthol cigarette smokers. These results confirm that menthol cigarettes are not safer than traditional cigarettes and suggest that menthol cigarette smokers may have more frequent severe exacerbations than non-menthol cigarette smokers.
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影响因子：
5.8
作者：
Mets OM;Schmidt M;Buckens CF;Gondrie MJ;Isgum I;Oudkerk M;Vliegenthart R;de Koning HJ;van der Aalst CM;Prokop M;Lammers JW;Zanen P;Mohamed Hoesein FA;Mali WP;van Ginneken B;van Rikxoort EM;de Jong PA
通讯作者：
de Jong PA
影响因子：
10
作者：
Martinez CH;Chen YH;Westgate PM;Liu LX;Murray S;Curtis JL;Make BJ;Kazerooni EA;Lynch DA;Marchetti N;Washko GR;Martinez FJ;Han MK;COPDGene Investigators
通讯作者：
COPDGene Investigators
影响因子：
4.2
作者：
Clemmey, P;Brooner, R;Stitzer, M
通讯作者：
Stitzer, M
影响因子：
6
作者：
Lawrence, Deirdre;Rose, Allison;Backinger, Cathy L.
通讯作者：
Backinger, Cathy L.
影响因子：
4.7
作者：
Ahijevych, K;Garrett, BE
通讯作者：
Garrett, BE