Secreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis?
Secreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis?
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DOI：
10.1111/pim.12166
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发表时间：
2015-03
影响因子：
2.2
通讯作者：
Boyle JP
中科院分区：
文献类型：
--
作者：
English ED;Adomako-Ankomah Y;Boyle JP
近年来，弓形虫体内发现了许多分泌蛋白，它们在宿主-病原体相互作用和寄生虫毒力中发挥重要作用，特别是在小鼠模型中。然而，这些蛋白质在驱动弓形虫与其最近的顶复门亲戚（Hammondia hammondi和Neospora caninum）相比的独特特征中所起的作用尚不清楚。这些独特的特征包括体内独特的传播特征和广泛的宿主范围。在这篇综述中，我们全面调查什么是已知的疾病的结果，宿主反应和宿主范围的弓形虫，哈蒙迪，和N.犬。然后，我们回顾了目前已知的最近确定的分泌毒力效应在这三个遗传相关，但表型不同，物种。最后，我们利用这三种生物的基因组序列的存在，并讨论什么是已知的存在，和功能，在这三个物种的关键弓形虫效应。
Recent years have witnessed the discovery of a number of secreted proteins in Toxoplasma gondii that play important roles in host–pathogen interactions and parasite virulence, particularly in the mouse model. However, the role that these proteins play in driving the unique features of T. gondii compared to some of its nearest apicomplexan relatives (Hammondia hammondi and Neospora caninum) is unknown. These unique features include distinct dissemination characteristics in vivo and a vast host range. In this review we comprehensively survey what is known about disease outcome, the host response and host range for T. gondii, H. hammondi, and N. caninum. We then review what is presently known about recently identified secreted virulence effectors in these three genetically related, but phenotypically distinct, species. Finally we exploit the existence of genome sequences for these three organisms and discuss what is known about the presence, and functionality, of key T. gondii effectors in these three species.
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