Reshapable polymeric hydrogel for controlled soft-tissue expansion: In vitro and in vivo evaluation.
Reshapable polymeric hydrogel for controlled soft-tissue expansion: In vitro and in vivo evaluation.
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DOI：
10.1016/j.jconrel.2017.07.029
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发表时间：
2017-09-28
期刊：
影响因子：
--
通讯作者：
Park K
中科院分区：
文献类型：
--
作者：
Garner J;Davidson D;Eckert GJ;Barco CT;Park H;Park K
组织扩张是使用从皮肤下方施加压力的装置产生额外皮肤的过程。在数周到数月的过程中，通过这种压力拉伸会产生一个额外的组织瓣，可以用来覆盖缺损区域或封闭永久性植入物。传统的组织扩张器需要通过外部注射盐水溶液或空气或通过亲水聚合物产生的内部渗透压来膨胀的硅树脂外壳。在这项研究中，无壳组织扩张器仅由化学交联的生物相容性聚合物水凝胶的开发。亲水性聚合物的交联网络在不存在外部膜的情况下提供固有控制的溶胀。使用大鼠皮肤动物模型，在体外和体内对新型水凝胶扩张器进行表征。发现增加水凝胶中的疏水聚酯含量将溶胀速度降低至消除过早溶胀使缝合区域破裂的危险的速率和体积。另外，增加交联密度导致水凝胶具有足够的机械强度以允许完全的溶胀后去除，而不会使水凝胶破裂或破碎。未观察到扩张器的全身毒性，组织学显示材料具有高度生物相容性。这些扩张器具有组织扩张的优点，而不需要外部硅树脂膜，因此，它们可以在植入时切割或重塑，以应用于身体的小区域或物理受限区域。
Tissue expansion is the process by which extra skin is generated using a device that applies pressure from underneath the skin. Over the course of weeks to months, stretching by this pressure creates a flap of extra tissue that can be used to cover a defect area or enclose a permanent implant. Conventional tissue expanders require a silicone shell inflated either by external injections of saline solution or air, or by internal osmotic pressure generated by a hydrophilic polymer. In this study, a shell-free tissue expander comprised only of a chemically cross-linked biocompatible polymeric hydrogel is developed. The cross-linked network of hydrophilic polymer provides for intrinsically controlled swelling in the absence of an external membrane. The new type of hydrogel expanders were characterized in vitro as well as in vivo using a rat-skin animal model. It was found that increasing the hydrophobic polyester content in the hydrogel reduced the swelling velocity to a rate and volume that eliminate the danger of premature swelling rupturing the sutured area. Additionally, increasing the crosslinking density resulted in enough mechanical strength of the hydrogel to allow for complete post-swelling removal, without the hydrogel cracking or crumbling. No systemic toxicity was noted with the expanders and histology showed the material to be highly biocompatible. These expanders have an advantage of tissue expansion without requiring an external silicone membrane, and thus, they can be cut or reshaped at the time of implantation for applications in small or physically constrained regions of the body.
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