Imipenem/cilastatin sodium (IPM/CS) as an embolic agent for transcatheter arterial embolisation: a preliminary clinical study of gastrointestinal bleeding from neoplasms.
Imipenem/cilastatin sodium (IPM/CS) as an embolic agent for transcatheter arterial embolisation: a preliminary clinical study of gastrointestinal bleeding from neoplasms.
复制标题
DOI：
10.1186/2193-1801-2-344
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Takigawa M
中科院分区：
文献类型：
--
作者：
Woodhams R;Nishimaki H;Ogasawara G;Fujii K;Yamane T;Ishida K;Kashimi F;Matsunaga K;Takigawa M
目的评价亚胺培南/西司他丁钠（IPM/CS）作为肠肿瘤出血栓塞剂的可行性和有效性。对2004年1月至2011年12月期间使用IPM/CS作为栓塞材料进行11次经动脉栓塞（TAE）治疗十二指肠或小肠/大肠肿瘤出血的7例患者进行了回顾性评价。通过位于供血动脉处的微导管将IPM/CS和造影剂的混合物引入肿瘤，直至外渗消失或观察到肿瘤染色的血流停滞。所有患者均获得止血。技术成功率为100%。在4例患者中观察到再出血。所有患者均使用IPM/CS进行重复TAE，并成功止血。实验室和临床检查后未发现并发症。未发生出血性死亡。出血参数，包括血液血红蛋白和输血量，改善后TAE。本研究表明，使用IPM/CS作为栓塞材料进行TAE治疗肿瘤性肠出血的安全性、可行性和有效性。IPM/CS的轻度栓塞作用可能足以治疗肿瘤渗出。尽管使用IPM/CS栓塞治疗后可能发生再出血，但重复栓塞是治疗再出血的有效方法。
To evaluate the feasibility and usefulness of imipenem/cilastatin sodium (IPM/CS) as an embolic agent for intestinal bleeding from neoplasms. Seven patients who underwent 11 transarterial embolisations (TAEs) using IPM/CS as an embolic material for duodenal or small/large intestinal tumour bleeding from January 2004 to December 2011 were retrospectively evaluated. A mixture of IPM/CS and contrast medium was introduced through the microcatheter positioned at the feeding artery to the tumour until extravasation disappeared or stasis of blood flow to the tumour staining was observed. Haemostasis was obtained in all patients. Therefore, the technical success rate was 100%. Rebleeding was observed in four patients. All of them underwent repeat TAE using IPM/CS, and haemostasis was obtained successfully. No complication was identified following laboratory and clinical examinations. No haemorrhagic death occurred. Haemorrhagic parameters, including blood haemoglobin and the amount of blood transfusion, improved after TAE. The safety, feasibility, and effectiveness of TAE using IPM/CS as an embolic material for intestinal bleeding from neoplasms were suggested by this study. The mild embolic effect of IPM/CS may be adequate for oozing from tumours. Although rebleeding may occur after embolotherapy using IPM/CS, repeat embolisation is effective as treatment for rebleeding.
登录
查看更多内容
影响因子：
5
作者：
GUY, GE;SHETTY, PC;BURKE, TH
通讯作者：
BURKE, TH
影响因子：
3
作者：
Gordon, RL;Ahl, KL;Welton, ML
通讯作者：
Welton, ML
影响因子：
2.9
作者：
Ledermann, HP;Schoch, E;Zollikofer, CL
通讯作者：
Zollikofer, CL
影响因子：
19.7
作者：
Defreyne, L;Vanlangenhove, P;Kunnen, M
通讯作者：
Kunnen, M
DOI：
10.1016/j.jvir.2013.02.033
发表时间：
2013-06-01
影响因子：
2.9
作者：
Okuno, Yuji;Matsumura, Noboru;Oguro, Sota
通讯作者：
Oguro, Sota