Hypertension-induced organ damage in african americans: Transforming growth factor-β1 excess as a mechanism for increased prevalence
Hypertension-induced organ damage in african americans: Transforming growth factor-β1 excess as a mechanism for increased prevalence
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非洲裔美国人高血压引起的器官损伤：转化生长因子-β1 过量是患病率增加的机制
DOI：
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发表时间：
2000
影响因子：
5.6
通讯作者：
M. Suthanthiran
中科院分区：
文献类型：
--
作者：
P. August;Beth Leventhal;M. Suthanthiran
高血压在全世界都很普遍，仅在美国就有超过 5000 万人受到影响。非裔美国人（黑人）的高血压患病率很高，发病年龄较早，并且患有严重或恶性高血压。他们还因高血压而发生靶器官损伤，包括左心室肥厚、中风、终末期肾病 (ESRD) 和冠状动脉疾病。与白人相比，高血压肾硬化在黑人中尤其普遍，有证据表明，除了血压升高之外，还有其他因素导致其发病。转化生长因子-β1 (TGF-β1) 是一种纤维形成细胞因子，与实验性和人类肾脏疾病的发生和进展有关。我们已经证明，与患有 ESRD 的白人相比，患有 ESRD 的黑人具有更高的 TGF-β1 蛋白循环水平。我们还发现，患有高血压的黑人中 TGF-b1 的过度表达比白人更常见。我们认为TGF-β1过度表达可能是高血压和高血压肾硬化的重要介质。我们还假设 TGF-β1 过度表达频率的增加可能导致黑人 ESRD 负担过重。根据我们的假设，以及血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂减少血管紧张素 II 介导的 TGF-β1 产生刺激的观察，我们建议使用这些药物治疗可能有效预防或减缓高血压黑人靶器官损伤的进展。
Hypertension is prevalent world-wide, and it affects over 50 million individuals in the United States alone. African Americans (blacks) have a high prevalence of hypertension, develop it at an earlier age, and suffer excessively from severe or malignant hypertension. They also have a high prevalence of target organ damage attributable to hypertension, including left ventricular hypertrophy, stroke, endstage renal disease (ESRD) and coronary artery disease. Hypertensive nephrosclerosis is particularly more prevalent in blacks compared to whites, and there is evidence that factors in addition to elevated blood pressure contribute to its pathogenesis. Transforming growth factor-beta 1 (TGF-β1) is a fibrogenic cytokine that has been implicated in the development and progression of experimental and human renal diseases. We have demonstrated that blacks with ESRD have higher circulating levels of TGF-β1 protein compared to whites with ESRD. We have also found that hyperexpression of TGF-b1 is more frequent in blacks with hypertension than in whites. We propose that TGF-β1 hyperexpression may be an important mediator of hypertension and hypertensive nephrosclerosis. We hypothesize also that the increased frequency of TGF-β1 hyperexpression may contribute to the excess burden of ESRD in blacks. Based on our hypotheses, and the observations that angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists reduce angiotensin II-mediated stimulation of TGF-β1 production, we propose that treatment with these agents might be efficacious in preventing or slowing the progression of target organ damage in hypertensive blacks.
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影响因子：
8.3
作者：
Border, WA;Noble, NA
通讯作者：
Noble, NA
影响因子：
8.3
作者：
Rosamond, WD;Folsom, AR;Shahar, E
通讯作者：
Shahar, E
影响因子：
19.6
作者：
Peters, H;Border, WA;Noble, NA
通讯作者：
Noble, NA
影响因子：
13.2
作者：
Bergman, S;Key, BO;Rostand, SG
通讯作者：
Rostand, SG
DOI：
10.1016/s0002-9629(15)40497-5
发表时间：
1999-03
期刊：
The American journal of the medical sciences
影响因子：
--
作者：
Jiang He;P. Whelton
通讯作者：
Jiang He;P. Whelton