On the origin of microparticles: From "platelet dust" to mediators of intercellular communication.

On the origin of microparticles: From "platelet dust" to mediators of intercellular communication.
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DOI:
10.4103/2045-8932.114760
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发表时间:
2013-04
影响因子:
2.6
通讯作者:
Bauer NN
Bauer NN
中科院分区:
医学4区
文献类型:
--
作者:
Hargett LA;Bauer NN

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微粒是从各种细胞中脱落的亚微米小泡。1967年,彼得·沃尔夫在正在进行的血液凝固研究中首次发现微粒是血小板的产物。他称它们为血小板尘埃。虽然最初被认为是无用的细胞垃圾,但几十年来对微小囊泡的研究已经确定了它们在凝血、细胞信号、血管损伤和动态平衡中的参与者角色。这篇综述的目的是强调导致微粒子发现的科学,介绍微粒子研究领域的关键贡献者的发现,并讨论它们对肺循环的积极和消极影响。
Microparticles are submicron vesicles shed from a variety of cells. Peter Wolf first identified microparticles in the midst of ongoing blood coagulation research in 1967 as a product of platelets. He termed them platelet dust. Although initially thought to be useless cellular trash, decades of research focused on the tiny vesicles have defined their roles as participators in coagulation, cellular signaling, vascular injury, and homeostasis. The purpose of this review is to highlight the science leading up to the discovery of microparticles, feature discoveries made by key contributors to the field of microparticle research, and discuss their positive and negative impact on the pulmonary circulation.
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