Engineered polymers for advanced drug delivery.
Engineered polymers for advanced drug delivery.
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DOI：
10.1016/j.ejpb.2008.09.021
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Park K
中科院分区：
文献类型：
--
作者：
Kim S;Kim JH;Jeon O;Kwon IC;Park K
工程聚合物已被用于开发先进的药物递送系统。这种聚合物的发展导致了聚合物化学的进步，这反过来又导致了智能聚合物，可以响应环境条件的变化，如温度，pH值和生物分子。从溶胀/去溶胀到降解，反应变化很大。药物-聚合物偶联物和含药纳米/微米颗粒已用于药物靶向。工程聚合物和聚合物系统也被用于新的领域，如分子成像和纳米技术。本文综述了工程聚合物已被用作传统的药物输送和更近期的应用在纳米技术。
Engineered polymers have been utilized for developing advanced drug delivery systems. The development of such polymers has caused advances in polymer chemistry, which, in turn, has resulted in smart polymers that can respond to changes in environmental condition, such as temperature, pH, and biomolecules. The responses vary widely from swelling/deswelling to degradation. Drug-polymer conjugates and drug-containing nano/micro-particles have been used for drug targeting. Engineered polymers and polymeric systems have also been used in new areas, such as molecular imaging as well as in nanotechnology. This review examines the engineered polymers that have been used as traditional drug delivery and as more recent applications in nanotechnology.
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