Transcriptome complexity in cardiac development and diseases--an expanding universe between genome and phenome.
Transcriptome complexity in cardiac development and diseases--an expanding universe between genome and phenome.
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DOI：
10.1253/circj.cj-14-0412
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Gao C;Wang Y
With the advancement of transcriptome profiling by micro-arrays and high-throughput RNA-sequencing, transcriptome complexity and its dynamics are revealed at different levels in cardiovascular development and diseases. In this review, we will highlight the recent progress in our knowledge of cardiovascular transcriptome complexity contributed by RNA splicing, RNA editing and noncoding RNAs. The emerging importance of many of these previously under-explored aspects of gene regulation in cardiovascular development and pathology will be discussed.
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