Vascular function in breast cancer survivors on aromatase inhibitors: a pilot study.
Vascular function in breast cancer survivors on aromatase inhibitors: a pilot study.
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DOI：
10.1007/s10549-017-4447-6
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发表时间：
2017-11
影响因子：
3.8
通讯作者：
Duprez D
中科院分区：
文献类型：
--
作者：
Blaes A;Beckwith H;Florea N;Hebbel R;Solovey A;Potter D;Yee D;Vogel R;Luepker R;Duprez D
芳香化酶抑制剂（AI）已被证明可以降低雌激素阳性（ER+）乳腺癌女性的乳腺癌相关死亡率。然而，AI的使用与高血压、高脂血症和心血管（CV）事件的发生率较高相关。对25名健康绝经后女性和36名接受AI治疗的乳腺癌女性进行了一项横断面研究，以评估内皮功能障碍，这是CV事件风险的一个指标。已确认的受试者使用HDI/Pulse Wave CR-2000心血管分析系统和EndoPAT 2000系统进行血管测试。平均年龄分别为61.7岁和59.6岁（病例，对照）。大多数受试者为白人和超重。对照组的平均收缩压较低（128.6 mmHg vs. 116.2 mmHg，p = 0.004）。病例中雌二醇水平中位数降低（2 vs. 15 pg/ml，p < 0.0001）。与对照相比，病例中的EndoPAT比率（0.8对2.7，p < 0.0001）显著降低。中位大动脉弹性（12.9 vs. 14.6 ml/mmHg × 10，p = 0.12）和小动脉弹性（5.2 vs. 7.0 ml/mmHg × 100，p = 0.07）也降低，但无统计学显著性。化疗、放疗、AI类型或AI使用时间与内皮功能之间无相关性。当调整血压差异时，结果仍然显着。接受AI治疗的乳腺癌病例内皮功能降低，这是不良CV疾病的预测因素。影响：与绝经后妇女相比，乳腺癌病例中AI的血管功能变化。需要进一步的工作来评估血管随时间的变化。
Aromatase inhibitors (AI) have been shown to reduce breast cancer-related mortality in women with estrogen positive (ER+) breast cancer. The use of AIs, however, has been associated with higher rates of hypertension, hyperlipidemia, and cardiovascular (CV) events. A cross-sectional study of 25 healthy post-menopausal women and 36 women with curative intent breast cancer on an AI was performed to assess endothelial dysfunction, an indicator of risk for CV events. Consented subjects underwent vascular testing using the HDI/Pulse Wave CR-2000 Cardiovascular Profiling System and the EndoPAT2000 system. Mean age was 61.7 and 59.6 years (cases, controls). Most subjects were Caucasian and overweight. Controls had a lower mean systolic blood pressure (128.6 mmHg vs. 116.2 mmHg, p = 0.004). Median estradiol levels were reduced in cases (2 vs. 15 pg/ml, p < 0.0001). EndoPAT ratio (0.8 vs. 2.7, p < 0.0001) was significantly reduced in cases as compared to controls. Median large artery elasticity (12.9 vs.14.6 ml/mmHg × 10, p = 0.12) and small artery elasticity (5.2 vs. 7.0 ml/mmHg × 100, p = 0.07) were also reduced though not statistically significant. There was no correlation between use of chemotherapy, radiation therapy, type of AI, or duration of AI use and endothelial function. When adjusting for differences in blood pressure, results remained significant. Breast cancer cases on AIs have reductions in endothelial function, a predictor of adverse CV disease. Impact: Vascular function changes in breast cancer cases on AIs compared to postmenopausal women. Further work is needed to evaluate vascular changes over time.
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DOI：
10.1016/s1470-2045(11)70270-4
发表时间：
2011-11
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Regan MM;Neven P;Giobbie-Hurder A;Goldhirsch A;Ejlertsen B;Mauriac L;Forbes JF;Smith I;Láng I;Wardley A;Rabaglio M;Price KN;Gelber RD;Coates AS;Thürlimann B;BIG 1-98 Collaborative Group;International Breast Cancer Study Group (IBCSG)
通讯作者：
International Breast Cancer Study Group (IBCSG)
影响因子：
3.8
作者：
Ligibel, Jennifer A.;O'Malley, A. James;Keating, Nancy L.
通讯作者：
Keating, Nancy L.
影响因子：
2.1
作者：
Luca, Mary Clare;Liuni, Andrew;Parker, John D.
通讯作者：
Parker, John D.
影响因子：
3.5
作者：
Shechter, Michael;Matetzky, Shlomi;Lerman, Amir
通讯作者：
Lerman, Amir
影响因子：
168.9
作者：
Albain, K.;Anderson, S.;Arriagada, R.;Barlow, W.;Bergh, J.;Bliss, J.;Buyse, M.;Cameron, D.;Carrasco, E.;Clarke, M.;Correa, C.;Coates, A.;Collins, R.;Costantino, J.;Cutter, D.;Cuzick, J.;Darby, S.;Davidson, N.;Davies, C.;Davies, K.;Delmestri, A.;Di Leo, A.;Dowsett, M.;Elphinstone, P.;Evans, V.;Ewertz, M.;Gelber, R.;Gettins, L.;Geyer, C.;Goldhirsch, A.;Godwin, J.;Gray, R.;Gregory, C.;Hayes, D.;Hill, C.;Ingle, J.;Jakesz, R.;James, S.;Kaufmann, M.;Kerr, A.;MacKinnon, E.;McGale, P.;McHugh, T.;Norton, L.;Ohashi, Y.;Paik, S.;Pan, H. C.;Perez, E.;Peto, R.;Piccart, M.;Pierce, L.;Pritchard, K.;Pruneri, G.;Raina, V.;Ravdin, P.;Robertson, J.;Rutgers, E.;Shao, Y. F.;Swain, S.;Taylor, C.;Valagussa, P.;Viale, G.;Whelan, T.;Winer, E.;Wang, Y.;Wood, W.
通讯作者：
Wood, W.