Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer.
Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer.
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DOI：
10.1186/gm331
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发表时间：
2012-04-30
期刊：
影响因子：
12.3
通讯作者：
Griffin JL
中科院分区：
文献类型：
--
作者：
Ament Z;Masoodi M;Griffin JL
过氧化物酶体增殖物激活受体（PPARs）是一组三种核激素受体，它们在调节代谢中起关键作用，特别是在进食和禁食状态之间的转换以及涉及脂肪酸氧化和脂质代谢的代谢途径中。此外，它们在新陈代谢之外还有许多重要的发育和调节作用。PPARs也是治疗II型糖尿病、血脂异常和肥胖症的有效靶点，尽管许多单独的激动剂也与不希望的副作用有关，并且PPARs与癌症的发展之间存在复杂的关系。本文综述了代谢组学，包括脂质组学，在阐明PPARs在调节全身代谢中的作用，以及它们在药物诱导的癌症和外源性代谢方面的作用方面所起的作用。这些研究已经确定了PPARδ在调节脂肪组织中脂肪酸氧化中的作用，以及衰老与肝脏中PPARα之间的相互作用。这些方法的潜在转化益处包括扩大PPAR激动剂的作用和改善药物疗效的监测。
The peroxisome proliferator-activated receptors (PPARs) are a set of three nuclear hormone receptors that together play a key role in regulating metabolism, particularly the switch between the fed and fasted state and the metabolic pathways involving fatty-acid oxidation and lipid metabolism. In addition, they have a number of important developmental and regulatory roles outside metabolism. The PPARs are also potent targets for treating type II diabetes, dyslipidemia and obesity, although a number of individual agonists have also been linked to unwanted side effects, and there is a complex relationship between the PPARs and the development of cancer. This review examines the part that metabolomics, including lipidomics, has played in elucidating the roles PPARs have in regulating systemic metabolism, as well as their role in aspects of drug-induced cancer and xenobiotic metabolism. These studies have defined the role PPARδ plays in regulating fatty-acid oxidation in adipose tissue and the interaction between aging and PPARα in the liver. The potential translational benefits of these approaches include widening the role of PPAR agonists and improved monitoring of drug efficacy.
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影响因子：
30.8
作者：
Kettunen, Johannes;Tukiainen, Taru;Sarin, Antti-Pekka;Ortega-Alonso, Alfredo;Tikkanen, Emmi;Lyytikainen, Leo-Pekka;Kangas, Antti J.;Soininen, Pasi;Wuertz, Peter;Silander, Kaisa;Dick, Danielle M.;Rose, Richard J.;Savolainen, Markku J.;Viikari, Jorma;Kahonen, Mika;Lehtimaki, Terho;Pietilainen, Kirsi H.;Inouye, Michael;McCarthy, Mark I.;Jula, Antti;Eriksson, Johan;Raitakari, Olli T.;Salomaa, Veikko;Kaprio, Jaakko;Jarvelin, Marjo-Riitta;Peltonen, Leena;Perola, Markus;Freimer, Nelson B.;Ala-Korpela, Mika;Palotie, Aarno;Ripatti, Samuli
通讯作者：
Ripatti, Samuli
影响因子：
30.8
作者：
通讯作者：
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影响因子：
2.3
作者：
Angermueller, Sabine;Islinger, Markus;Voelkl, Alfred
通讯作者：
Voelkl, Alfred
影响因子：
4.5
作者：
Gonzalez, Frank J.;Shah, Yatrik A.
通讯作者：
Shah, Yatrik A.
影响因子：
2.6
作者：
Connor, SC;Hodson, MP;Haselden, JN
通讯作者：
Haselden, JN