Frequency changes in a continuous tone: auditory cortical potentials.

Frequency changes in a continuous tone: auditory cortical potentials.
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DOI:
10.1016/j.clinph.2008.06.002
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发表时间:
2008-09
期刊:
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子:
--
通讯作者:
Starr A
Starr A
中科院分区:
其他
文献类型:
--
作者:
Dimitrijevic A;Michalewski HJ;Zeng FG;Pratt H;Starr A

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我们研究了听力正常受试者在连续低频和高频纯音频谱变化的听觉皮层电位。皮层电位记录的频率从连续的250 Hz或4000 Hz的音调的增量。变化的幅度是随机的,在基频以上0%至50%之间变化。电位由N100、P200和慢负波(SN)组成。N100振幅,潜伏期和偶极子幅度与频率增量显着更大的低相比,高频率。两个基频的偶极子振幅在右半球都比左半球大。SN幅频变化在4 - 50%之间与频谱变化幅度无显著相关性。由频谱变化引起的N100振幅和潜伏期的调制在低频下比在高频下更明显。这些数据提供的电生理证据表明,中央处理的频谱变化在皮层不同的低和高的频率。这些差异中的一些可能与听觉外围的基于时间和基于频谱的编码有关。频率变化的中心表示可能与跨频率的积分的不同时间窗口有关。
We examined auditory cortical potentials in normal hearing subjects to spectral changes in continuous low and high frequency pure tones. Cortical potentials were recorded to increments of frequency from continuous 250 Hz or 4000 Hz tones. The magnitude of change was random and varied from 0% to 50% above the base frequency. Potentials consisted of N100, P200 and a slow negative wave (SN). N100 amplitude, latency and dipole magnitude with frequency increments were significantly greater for low compared to high frequencies. Dipole amplitudes were greater in the right than left hemisphere for both base frequencies. The SN amplitude to frequency changes between 4 to 50% was not significantly related to the magnitude of spectral change. Modulation of N100 amplitude and latency elicited by spectral change is more pronounced with low compared to high frequencies. These data provide electrophysiological evidence that central processing of spectral changes in the cortex differs for low and high frequencies. Some of these differences may be related to both temporal- and spectral-based coding at the auditory periphery. Central representation of frequency change may be related to the different temporal windows of integration across frequencies.
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