Altered cortical communication in amyotrophic lateral sclerosis.
Altered cortical communication in amyotrophic lateral sclerosis.
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DOI：
10.1016/j.neulet.2013.03.028
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发表时间：
2013-05-24
影响因子：
2.5
通讯作者：
Lee U
中科院分区：
文献类型：
--
作者：
Blain-Moraes S;Mashour GA;Lee H;Huggins JE;Lee U
肌萎缩侧索硬化症（ALS）是一种主要与运动系统变性相关的疾病。最近，功能连接研究已经证明了ALS大脑组织的潜在适应性变化，但与疾病相关的皮层通信变化仍然未知。我们招募了ALS患者和年龄匹配的对照组来操作脑机接口，同时记录了三次脑电图。使用归一化的符号传递熵，我们测量了从额叶到顶叶（反馈连接）和顶叶到额叶（前馈连接）区域的定向功能连接。反馈连接在组间没有显著差异，但前馈连接在ALS患者中显著更高。这一结果在广泛的脑电图频谱（4 - 35 Hz）以及θ、α和β频带中是一致的。反馈连接与意识状态相关，并且在这项研究中发现与ALS症状严重程度无关，这可能对晚期ALS患者的意识检测具有重要意义。我们认为，前馈连接的增加代表了对ALS相关输入损失的补偿性反应，使得感觉刺激具有足够的强度来跨越全局神经元工作空间中有意识处理所需的阈值。
Amyotrophic lateral sclerosis (ALS) is a disorder associated primarily with the degeneration of the motor system. More recently, functional connectivity studies have demonstrated potentially adaptive changes in ALS brain organization, but disease-related changes in cortical communication remain unknown. We recruited individuals with ALS and age-matched controls to operate a brain-computer interface while electroencephalography was recorded over three sessions. Using normalized symbolic transfer entropy, we measured directed functional connectivity from frontal to parietal (feedback connectivity) and parietal to frontal (feedforward connectivity) regions. Feedback connectivity was not significantly different between groups, but feedforward connectivity was significantly higher in individuals with ALS. This result was consistent across a broad electroencephalographic spectrum (4 – 35 Hz), and in theta, alpha and beta frequency bands. Feedback connectivity has been associated with conscious state and was found to be independent of ALS symptom severity in this study, which may have significant implications for the detection of consciousness in individuals with advanced ALS. We suggest that increases in feedforward connectivity represent a compensatory response to the ALS-related loss of input such that sensory stimuli have sufficient strength to cross the threshold necessary for conscious processing in the global neuronal workspace.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
2.6
作者：
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通讯作者：
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作者：
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通讯作者：
Walsh, V