TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells.
TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells.
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TIM-4是一种磷脂酰丝氨酸的受体，通过调节去除抗原特异性T细胞来控制适应性免疫。
DOI：
10.4049/jimmunol.1001360
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发表时间：
2010-12-01
期刊：
影响因子：
--
通讯作者：
DeKruyff RH
中科院分区：
文献类型：
--
作者：
Albacker LA;Karisola P;Chang YJ;Umetsu SE;Zhou M;Akbari O;Kobayashi N;Baumgarth N;Freeman GJ;Umetsu DT;DeKruyff RH
适应性免疫的特征在于Ag暴露后Ag特异性T细胞群的扩增。然而，控制Ag特异性T细胞数量的扩增和随后的收缩的精确机制还没有完全理解。我们表明，T细胞/跨膜，IG，和粘蛋白（TIM）-4，磷脂酰丝氨酸的受体，凋亡细胞的标志物，调节适应性免疫的一部分，介导的Ag特异性T细胞在收缩期的反应。在Ag免疫期间或在用甲型流感病毒感染期间，阻断TIM-4对APC的作用增加了Ag特异性T细胞的扩增，导致二次免疫应答的增加。相反，在转基因小鼠中APC上TIM-4的过表达减少了免疫后保留的Ag特异性T细胞的数量，导致次级T细胞应答减少。在TIM-4转基因小鼠中，T细胞完成的细胞分裂总数没有变化，剩余Ag特异性T细胞的每细胞增殖能力没有变化，Ag特异性调节性T细胞的发育没有增加。因此，TIM-4表达细胞通过介导表达磷脂酰丝氨酸的凋亡的Ag特异性T细胞的去除来调节适应性免疫，从而控制Ag清除或感染后剩余的Ag特异性T细胞的数量。
Adaptive immunity is characterized by the expansion of an Ag-specific T cell population following Ag exposure. The precise mechanisms, however, that control the expansion and subsequent contraction in the number of Ag-specific T cells are not fully understood. We show that T cell/transmembrane, Ig, and mucin (TIM)-4, a receptor for phosphatidylserine, a marker of apoptotic cells, regulates adaptive immunity in part by mediating the removal of Ag-specific T cells during the contraction phase of the response. During Ag immunization or during infection with influenza A virus, blockade of TIM-4 on APCs increased the expansion of Ag-specific T cells, resulting in an increase in secondary immune responses. Conversely, overexpression of TIM-4 on APCs in transgenic mice reduced the number of Ag-specific T cells that remained after immunization, resulting in reduced secondary T cell responses. There was no change in the total number of cell divisions that T cells completed, no change in the per cell proliferative capacity of the remaining Ag-specific T cells, and no increase in the development of Ag-specific regulatory T cells in TIM-4 transgenic mice. Thus, TIM-4–expressing cells regulate adaptive immunity by mediating the removal of phosphatidylserine-expressing apoptotic, Ag-specific T cells, thereby controlling the number of Ag-specific T cells that remain after the clearance of Ag or infection.
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影响因子：
64.5
作者：
Kaech, SM;Hemby, S;Ahmed, R
通讯作者：
Ahmed, R
影响因子：
32.4
作者：
Hughes, Peter D.;Belz, Gabrielle T.;Fortner, Karen A.;Budd, Ralph C.;Strasser, Andreas;Bouillet, Philippe
通讯作者：
Bouillet, Philippe
DOI：
10.1073/pnas.0538056100
发表时间：
2003-03-04
影响因子：
11.1
作者：
Johnson, BJ;Costelloe, EO;Kelso, A
通讯作者：
Kelso, A
影响因子：
3.9
作者：
Borisenko, GG;Matsura, T;Kagan, VE
通讯作者：
Kagan, VE
影响因子：
8.7
作者：
Freeman GJ;Casasnovas JM;Umetsu DT;DeKruyff RH
通讯作者：
DeKruyff RH