Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity.
Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity.
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DOI：
10.1088/1748-605x/ac5574
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发表时间：
2022-03-04
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
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作者：
植入的生物材料引起一系列不同的免疫和修复样反应，统称为异物反应（FBR）。这些包括涉及先天免疫炎性细胞和伤口修复细胞的过程，这些过程有助于用致密的胶原性和大部分无血管的囊包封生物材料。许多研究表明，早期阶段由巨噬细胞主导，巨噬细胞融合形成异物巨细胞，这被认为是FBR的标志。随着更精确的细胞表征技术的出现，特定的巨噬细胞亚群已被鉴定并与或多或少的有利结果相关联。此外，比较合成和天然聚合物生物材料的研究已经允许识别区分纤维化和再生反应的巨噬细胞亚型。最近，与适应性免疫相关的细胞已被证明参与合成聚合物的FBR。这表明先天免疫细胞和适应性免疫细胞之间存在串扰，这取决于植入物的性质。然而，适应性免疫细胞如T和B细胞的确切参与仍不清楚。事实上，相互矛盾的研究表明FBR对这些细胞的独立性或依赖性。在这里，我们审查的证据参与适应性免疫FBR合成聚合物的细胞和分子成分的重点。此外，我们还研究了这种生物材料诱导特异性抗体反应导致适应性免疫细胞参与的可能性。
Implanted biomaterials elicit a series of distinct immune and repair-like responses that are collectively known as the foreign body reaction (FBR). These include processes involving innate immune inflammatory cells and wound repair cells that contribute to the encapsulation of biomaterials with a dense collagenous and largely avascular capsule. Numerous studies have shown that the early phase is dominated by macrophages that fuse to form foreign body giant cells that are considered a hallmark of the FBR. With the advent of more precise cell characterization techniques, specific macrophage subsets have been identified and linked to more or less favorable outcomes. Moreover, studies comparing synthetic- and natural-based polymer biomaterials have allowed the identification of macrophage subtypes that distinguish between fibrotic and regenerative responses. More recently, cells associated with adaptive immunity have been shown to participate in the FBR to synthetic polymers. This suggests the existence of cross-talk between innate and adaptive immune cells that depends on the nature of the implants. However, the exact participation of adaptive immune cells, such as T and B cells, remains unclear. In fact, contradictory studies suggest either the independence or dependence of the FBR on these cells. Here, we review the evidence for the involvement of adaptive immunity in the FBR to synthetic polymers with a focus on cellular and molecular components. In addition, we examine the possibility that such biomaterials induce specific antibody responses resulting in the engagement of adaptive immune cells.
影响因子：
4.9
作者：
Bracaglia, Laura G.;Winston, Shira;Powell, Douglas A.;Fisher, John P.
通讯作者：
Fisher, John P.