Improvements to cardiovascular gene ontology.
Improvements to cardiovascular gene ontology.
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DOI：
10.1016/j.atherosclerosis.2008.10.014
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发表时间：
2009-07
期刊：
影响因子：
5.3
通讯作者：
Talmud, Philippa J.
中科院分区：
文献类型：
--
作者：
Lovering, Ruth C.;Dimmer, Emily C.;Talmud, Philippa J.
基因本体（GO）提供了一个受控的词汇表来描述任何生物体中的基因和基因产物的属性。虽然人们最初可能想知道什么相关性的“控制词汇”可能有心血管科学，这样的资源被证明是非常有用的研究人员调查复杂的心血管疾病表型以及那些解释结果的高通量方法。GO使单个基因的当前功能知识能够用于注释基因组或蛋白质组数据集。通过这种方式，GO数据提供了一种非常有效的方式，将生物学知识与后基因组学研究的大型数据集分析联系起来。因此，高通量方法的用户，如表达阵列或蛋白质组学将是这种注释集的主要受益者。然而，随着GO注释在质量和数量上的提高，使用小规模方法的团体也将逐渐开始受益。例如，冠状动脉心脏病的全基因组关联扫描正在识别新基因，这些新基因与心血管过程有着以前未知的联系，对这些新基因的全面注释可能会为它们与心血管的联系提供线索。迄今为止，至少有4000个基因与心血管过程有关，目前正在开展一项倡议，重点是注释这些基因，以造福心血管社区。在这篇文章中，我们回顾了基因本体论注释的当前用途，以突出为什么基因本体论应该是所有参与心血管研究的人感兴趣的。
Gene Ontology (GO) provides a controlled vocabulary to describe the attributes of genes and gene products in any organism. Although one might initially wonder what relevance a ‘controlled vocabulary’ might have for cardiovascular science, such a resource is proving highly useful for researchers investigating complex cardiovascular disease phenotypes as well as those interpreting results from high-throughput methodologies. GO enables the current functional knowledge of individual genes to be used to annotate genomic or proteomic datasets. In this way, the GO data provides a very effective way of linking biological knowledge with the analysis of the large datasets of post-genomics research. Consequently, users of high-throughput methodologies such as expression arrays or proteomics will be the main beneficiaries of such annotation sets. However, as GO annotations increase in quality and quantity, groups using small-scale approaches will gradually begin to benefit too. For example, genome wide association scans for coronary heart disease are identifying novel genes, with previously unknown connections to cardiovascular processes, and the comprehensive annotation of these novel genes might provide clues to their cardiovascular link. At least 4000 genes, to date, have been implicated in cardiovascular processes and an initiative is underway to focus on annotating these genes for the benefit of the cardiovascular community. In this article we review the current uses of Gene Ontology annotation to highlight why Gene Ontology should be of interest to all those involved in cardiovascular research.
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影响因子：
4.3
作者：
Cohen KB;Hunter L
通讯作者：
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影响因子：
7
作者：
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DOI：
10.1073/pnas.0308174101
发表时间：
2004-02-24
影响因子：
11.1
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DOI：
10.1097/nen.0b013e318163354a
发表时间：
2008-02-01
影响因子：
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作者：
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