Techno‐economic modeling and assessment of cultivated meat: Impact of production bioreactor scale
Techno‐economic modeling and assessment of cultivated meat: Impact of production bioreactor scale
复制标题
人造肉的技术经济建模和评估：生产生物反应器规模的影响
DOI：
10.1002/bit.28324
复制
发表时间：
2023
影响因子：
3.8
通讯作者：
McDonald, Karen A.
中科院分区：
文献类型：
--
作者：
Negulescu, Patrick G.;Risner, Derrick;Spang, Edward S.;Sumner, Daniel;Block, David;Nandi, Somen;McDonald, Karen A.
全球肉类需求的增长无法以目前的畜牧业方法可持续地满足，这对温室气体排放、土地使用、水消耗和农场动物福利产生了重大影响。人工养殖肉是一项快速发展的技术，通过在大型生物反应器中增殖和分化动物干细胞来生产肉制品，避免了传统的活动物养殖。虽然许多公司都在这一领域开展工作，但缺乏现有的基础设施和商业规模的经验，导致许多技术瓶颈，如细胞培养的规模扩大和培养基的可用性和成本。在这项研究中，我们评估了理论上的养殖牛肉生产设施，目标是设想一个拥有多个设施的行业，每年生产100，000，000公斤养殖牛肉，占全球牛肉年产量的0.14%。使用计算机辅助工艺设计软件SuperPro Designer®，对设施进行建模，以创建全面的分析，突出可以降低生产系统成本并使养殖肉制品具有竞争力的改进。采用不同尺寸的生产反应器提供了三种设施方案：约42，000 L搅拌罐生物反应器（STR），基本情况商品销售成本（COGS）为35美元/kg，约211，000 L STR，COGS为25美元/kg，约262，000 L气升式反应器（ALR），COGS为17美元/kg。这项研究概述了如何扩大规模的生物反应器，替代生物反应器的设计，并降低媒体成本的进步是必要的商业化培养肉制品。
Increases in global meat demands cannot be sustainably met with current methods of livestock farming, which has a substantial impact on greenhouse gas emissions, land use, water consumption, and farm animal welfare. Cultivated meat is a rapidly advancing technology that produces meat products by proliferating and differentiating animal stem cells in large bioreactors, avoiding conventional live‐animal farming. While many companies are working in this area, there is a lack of existing infrastructure and experience at commercial scale, resulting in many technical bottlenecks such as scale‐up of cell culture and media availability and costs. In this study, we evaluate theoretical cultivated beef production facilities with the goal of envisioning an industry with multiple facilities to produce in total 100,000,000 kg of cultured beef per year or ~0.14% of the annual global beef production. Using the computer‐aided process design software, SuperPro Designer®, facilities are modeled to create a comprehensive analysis to highlight improvements that can lower the cost of such a production system and allow cultivated meat products to be competitive. Three facility scenarios are presented with different sized production reactors; ~42,000 L stirred tank bioreactor (STR) with a base case cost of goods sold (COGS) of $35/kg, ~211,000 L STR with a COGS of $25/kg, and ~262,000 L airlift reactor (ALR) with a COGS of $17/kg. This study outlines how advances in scaled up bioreactors, alternative bioreactor designs, and decreased media costs are necessary for commercialization of cultured meat products.
登录
查看更多内容
微流体细胞培养装置中胚胎干细胞的特定氧气吸收速率的实时监测。
影响因子：
4.7
作者：
Super, Alexandre;Jaccard, Nicolas;Marques, Marco Paulo Cardoso;Macown, Rhys Jarred;Griffin, Lewis D.;Veraitch, Farlan Singh;Szita, Nicolas
通讯作者：
Szita, Nicolas
影响因子：
6.4
作者：
O'Neill, Edward N.;Ansel, Joshua C.;Kwong, Grace A.;Plastino, Michael E.;Nelson, Jenny;Baar, Keith;Block, David E.
通讯作者：
Block, David E.
影响因子：
8.1
作者：
Gotham D;Barber MJ;Hill A
通讯作者：
Hill A
用于去除污染空气中二氯甲烷的生物滴滤池和三相气升式生物反应器的比较放大和成本估算
DOI：
10.1080/10473289.1997.10464047
发表时间：
1997
影响因子：
2.7
作者：
L. Zuber;I. Dunn;M. Deshusses
通讯作者：
M. Deshusses
食品工厂经济学
影响因子：
6.4
作者：
Z. Maroulis;G. Saravacos
通讯作者：
G. Saravacos