C-C Chemokine Receptor Seven (CCR7): Coming of Age In Vaccines
C-C Chemokine Receptor Seven (CCR7): Coming of Age In Vaccines
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C-C 趋化因子受体七 (CCR7)：疫苗的成熟
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
C. Vines
中科院分区：
文献类型：
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作者：
C. A. Bill;Olga B Soto;C. Vines
在与非医疗人员的随意交谈中，他们经常会问：为什么我们没有治愈癌症的方法或所有疾病的疫苗？似乎有些合乎逻辑的假设是，经过这么多年的研究，治疗方法应该是现成的，一般疾病只需要吃一片药或打一针，而且不知何故，如果科学家没有故意隐瞒这些治疗方法，那么他们肯定是在开车时睡着了。对这类问题的典型回答集中在不同癌症/疾病的复杂性上，也就是说不会有“万能的灵丹妙药”。说到疫苗接种，毫无疑问，许多疫苗是非常有效的，许多出版物可以证明这一点，并列举了我们的疫苗接种计划拯救了多少人的生命；事实上，疫苗通常会出现在一系列原因清单上，为什么今天的人类比历史上任何时候都活得更长。1-3然而，总是有一个压倒一切的、在某种程度上令人尴尬的认识到，尽管疫苗取得了相对的成功，但在大多数情况下，我们仍然不知道如何制造持续有效的疫苗，而且往往归结为一种反复试验的过程，以确定针对给定目标的最佳疫苗。
In casual conversation with non-medical individuals, it is common for them to ask: why do we not have a cure for cancer or vaccinations for all diseases? It seems somewhat logical to assume that after so many years of research that cures should be readily available, diseases in general should simply require a pill or jab and that somehow, if scientists are not deliberately hiding these cures, then they must be asleep at the wheel. A typical response to such questions focuses on the complexity of the different cancers/diseases and that there will be no “one cure fits all”. When it comes to vaccinations, there is absolutely no doubt that many vaccines are extremely effective and a multitude of publications can attest to this and cite how many lives have been saved because of our vaccination programs; indeed, vaccinations typically pop up on a list of reasons why humans today are living substantially longer than at any previous time in history.1-3 Nevertheless, there is always an overriding and to some extent embarrassing realization that despite the relative success of vaccines we still do not, for the most part, know how to make consistently effective vaccines and that often it boils down to a trial and error procedure to establish the best vaccine for a given target
影响因子：
32.4
作者：
Martin, F;Oliver, AM;Kearney, JF
通讯作者：
Kearney, JF