The effect of the chemical, biological, and physical environment on quorum sensing in structured microbial communities.
The effect of the chemical, biological, and physical environment on quorum sensing in structured microbial communities.
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DOI：
10.1007/s00216-006-0720-y
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发表时间：
2007-01
影响因子：
4.3
通讯作者：
Parsek, Matthew R.
中科院分区：
文献类型：
--
作者：
Horswill, Alexander R.;Stoodley, Paul;Stewart, Philip S.;Parsek, Matthew R.
当研究人员试图在相关的临床或环境环境中研究群体感应时，很明显许多因素都有可能影响信号传导。这些因素涵盖了一系列物理，化学和生物变量，可以影响信号的产生，稳定性和分布。优化实验系统的自然或临床环境可能是至关重要的，以确定何时何地发生群体感应。这些观点在我们对S.金黄色葡萄球菌的信号在生物膜，其中信号的稳定性可能会受到影响的主机环境。一些主要的群体感应系统的基本信号方案已经在分子水平上制定出来。随着这些研究不断完善我们对这些机制的理解，一个新出现的挑战是确定当地环境是否以及何时会影响信号传导。
As researchers attempt to study quorum sensing in relevant clinical or environmental settings, it is apparent that many factors have the potential to affect signaling. These factors span a range of physical, chemical, and biological variables that can impact signal production, stability and distribution. Optimizing experimental systems to natural or clinical environments may be crucial for defining when and where quorum sensing occurs. These points are illustrated in our case study of S. aureus signaling in biofilms, where signal stability may be affected by the host environment. The basic signaling schemes have been worked out at the molecular level for a few of the major quorum-sensing systems. As these studies continue to refine our understanding of these mechanisms, an emerging challenge is to identify if and when the local environment can affect signaling.
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3.1
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