Ablation of PPARγ in subcutaneous fat exacerbates age-associated obesity and metabolic decline.
Ablation of PPARγ in subcutaneous fat exacerbates age-associated obesity and metabolic decline.
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皮下脂肪中 PPAR γ 的消除会加剧与年龄相关的肥胖和代谢下降
DOI：
10.1111/acel.12721
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发表时间：
2018-04
期刊：
影响因子：
7.8
通讯作者：
Mueller E
中科院分区：
文献类型：
--
作者：
Xu L;Ma X;Verma NK;Wang D;Gavrilova O;Proia RL;Finkel T;Mueller E
众所周知，衰老与代谢功能障碍有关，如肥胖增加和能量耗散受损;然而，在生命后期调节能量平衡的转录机制尚未完全阐明。在这里，我们表明，在老龄小鼠腹股沟脂肪组织中特异性核受体PPARγ的消融与脂肪组织扩张和胰岛素抵抗增加有关。这些代谢效应伴随着产热减少、棕色脂肪基因水平降低和皮下脂肪组织的布朗宁。在年轻和中年小鼠中进行的PPARγ下调效应的比较研究表明，腹股沟脂肪中棕色脂肪基因程序以年龄依赖性方式优先调节。总之，我们的研究揭示了PPARγ在衰老过程中维持能量消耗的重要作用，并提出了靶向PPARγ以抵消年龄相关代谢功能障碍的可能性。
It is well established that aging is associated with metabolic dysfunction such as increased adiposity and impaired energy dissipation; however, the transcriptional mechanisms regulating energy balance during late life stages have not yet been fully elucidated. Here, we show that ablation of the nuclear receptor PPARγ specifically in inguinal fat tissue in aging mice is associated with increased fat tissue expansion and insulin resistance. These metabolic effects are accompanied by decreased thermogenesis, reduced levels of brown fat genes, and browning of subcutaneous adipose tissue. Comparative studies of the effects of PPARγ downregulation in young and mid‐aged mice demonstrate a preferential regulation of brown fat gene programs in inguinal fat in an age‐dependent manner. In conclusion, our study uncovers an essential role for PPARγ in maintaining energy expenditure during the aging process and suggests the possibility of targeting PPARγ to counteract age‐associated metabolic dysfunction.
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影响因子：
168.9
作者：
Christensen, Kaare;Doblhammer, Gabriele;Rau, Roland;Vaupel, James W.
通讯作者：
Vaupel, James W.
影响因子：
29
作者：
Ma, Xinran;Xu, Lingyan;Mueller, Elisabetta
通讯作者：
Mueller, Elisabetta
影响因子：
4.8
作者：
Mueller, E;Drori, S;Spiegelman, BM
通讯作者：
Spiegelman, BM
DOI：
10.1073/pnas.2536828100
发表时间：
2003-12-23
影响因子：
11.1
作者：
He, WM;Barak, Y;Evans, RM
通讯作者：
Evans, RM
影响因子：
29
作者：
Ohno H;Shinoda K;Spiegelman BM;Kajimura S
通讯作者：
Kajimura S