Vocal acoustic biomarkers of depression severity and treatment response.
Vocal acoustic biomarkers of depression severity and treatment response.
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DOI：
10.1016/j.biopsych.2012.03.015
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发表时间：
2012-10-01
影响因子：
10.6
通讯作者：
Lenderking, William R.
中科院分区：
文献类型：
--
作者：
Mundt, James C.;Vogel, Adam P.;Feltner, Douglas E.;Lenderking, William R.
有效、可靠的抑郁症严重程度和治疗反应的生物标志物将为临床研究提供新的靶点。抑郁症患者和非抑郁症患者之间言语产生的显著差异被认为是一种潜在的生物标志物。105名患有严重抑郁症的成年人被招募到一项为期四周的随机、双盲、安慰剂对照研究方法学研究中。该研究的探索性目的是评估先前研究结果的普遍性和可重复性，这些结果表明语音中的声音声学特性可以作为抑郁症严重程度和治疗反应的生物标志物。语音样本，收集在基线和研究终点使用自动电话系统，作为临床医生评定和患者报告的抑郁症严重程度和治疗反应的措施的函数进行分析。尽管两项研究的方法设计和实施存在差异，但在先前的研究中，与临床结局相关的语音模式变化的回归模型被认为是当前研究中结局的可靠和重要的预测因素。当前研究的结果重复并支持先前研究的结果。对所提供的治疗有反应的患者中抑郁症状的临床变化也反映了言语产生模式的显着差异。临床上没有改善的抑郁患者表现出较小的声音声学变化和/或与治疗应答者方向相反的变化。这项研究支持的可行性和有效性，获得临床上重要的，生物为基础的声乐声学措施抑郁症的严重程度和治疗反应，使用自动电话系统。美国国立卫生研究院临床试验注册处：http://clinicaltrials.gov标识符：NCT 00406952。
Valid, reliable biomarkers of depression severity and treatment response would provide new targets for clinical research. Noticeable differences in speech production between depressed and nondepressed patients have been suggested as a potential biomarker. One hundred and five adults with Major Depression were recruited into a four-week, randomized, double-blind, placebo-controlled research methodology study. An exploratory objective of the study was to evaluate the generalizability and repeatability of prior study results indicating vocal acoustic properties in speech may serve as biomarkers for depression severity and response to treatment. Speech samples, collected at baseline and study end-point using an automated telephone system, were analyzed as a function of clinician-rated and patient-reported measures of depression severity and treatment response. Regression models of speech pattern changes associated with clinical outcomes in the prior study were found to be reliable and significant predictors of outcome in the current study despite differences in the methodological design and implementation of the two studies. Results of the current study replicate and support findings from the prior study. Clinical changes in depressive symptoms among patients responding to the treatments provided also reflected significant differences in speech production patterns. Depressed patients who did not improve clinically showed smaller vocal acoustic changes and/or changes that were directionally opposite to treatment responders. This study supports the feasibility and validity of obtaining clinically important, biologically-based vocal acoustic measures of depression severity and treatment response using an automated telephone system. National Institutes of Health Clinical Trials Registry: http://clinicaltrials.gov Identifier: NCT00406952.
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