Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.
Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.
复制标题
DOI：
10.4161/epi.5.1.10449
复制
发表时间：
2010-01-01
期刊：
影响因子：
3.7
通讯作者：
Brindle PK
中科院分区：
文献类型：
--
作者：
Bedford DC;Kasper LH;Fukuyama T;Brindle PK
基因调控的一个一般原理是，DNA结合的转录因子通过招募改变组蛋白和染色质结构的辅助因子来调节转录。第二个隐含的原则是，在招募辅因子的所有靶基因中，特定的辅因子是必需的。随着转录、辅因子和染色质修饰之间的实验定义的关系变得越来越复杂，这些原则似乎越来越不是绝对的。KAT3组蛋白乙酰转移酶CREB结合蛋白(CBP)和p300至少有400个相互作用的蛋白质对，因此在基因调控网络中扮演着枢纽的角色。使用突变原代细胞的研究表明，CBP和p300在任何给定的目标基因上的出现有时与转录相关，而不是决定转录。这表明CBP/p300和其他无关的共激活因子之间存在意想不到的冗余，或者CBP/p300的招募有时可能是巧合的。因此，转录因子可能会招募同一组共激活因子作为其“工具箱”的一部分，但正是单个靶基因的特征决定了它的转录需要哪些共激活“工具”。
One general principle of gene regulation is that DNA-binding transcription factors modulate transcription by recruiting cofactors that modify histones and chromatin structure. A second implicit principle is that a particular cofactor is necessary at all the target genes where the cofactor is recruited. Increasingly, these principles do not appear to be absolute, as experimentally defined relationships between transcription, cofactors, and chromatin modification grow in complexity. The KAT3 histone acetyltransferases CREB binding protein (CBP) and p300 have at least 400 interacting protein partners, thereby acting as hubs in gene regulatory networks. Studies using mutant primary cells indicate that the occurrence of CBP and p300 at any given target gene sometimes correlates with, rather than dictates transcription. This suggests that there are unexpected levels of redundancy between CBP/p300 and other unrelated coactivators, or that CBP/p300 recruitment may sometimes be coincidental. A transcription factor may therefore recruit the same group of coactivators as part of its “toolbox”, but it is the characteristics of the individual target gene that determine which coactivation “tools” are required for its transcription.
登录
查看更多内容
DOI：
10.1073/pnas.1834280100
发表时间：
2003-09-02
影响因子：
11.1
作者：
Bourtchouladze, R;Lidge, R;Tully, T
通讯作者：
Tully, T
影响因子：
64.8
作者：
Jeong, H;Mason, SP;Oltvai, ZN
通讯作者：
Oltvai, ZN
影响因子：
5.3
作者：
Hussain, Mehboob A.;Porras, Delia L.;Wondisford, Fredric E.
通讯作者：
Wondisford, Fredric E.
影响因子：
2.7
作者：
Elliott, Aaron M.;de Miguel, Maria P.;Donovan, Peter J.
通讯作者：
Donovan, Peter J.
影响因子：
50.3
作者：
Kang-Decker, N;Tong, CL;van Deursen, JMA
通讯作者：
van Deursen, JMA