Paired CT Measures of Emphysema and Small Airways Disease and Lung Function and Exercise Capacity in Smokers with Radiographic Bronchiectasis.
Paired CT Measures of Emphysema and Small Airways Disease and Lung Function and Exercise Capacity in Smokers with Radiographic Bronchiectasis.
复制标题
x线支气管扩张吸烟者肺气肿、小气道疾病、肺功能和运动能力的配对CT测量。
DOI：
10.1016/j.acra.2020.02.013
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发表时间：
2021-03
影响因子：
4.8
通讯作者：
Diaz AA
中科院分区：
文献类型：
--
作者：
Martinez CH;Okajima Y;Yen A;Maselli DJ;Nardelli P;Rahaghi F;Young K;Kinney G;Hatt C;Galban C;Washko GR;Han M;Estépar RSJ;Diaz AA
支气管扩张(BE)与慢性阻塞性肺疾病(COPD)相关，但COPD的主要病理特征--肺气肿和小气道疾病在BE中研究较少。我们的目标是客观地评估有和没有BE的吸烟者的这些特征，并检查其与气流阻塞和运动能力的关系。我们用参数反应图(PRMEMPH和PRMSAD)方法对1184名吸烟者进行了吸气-呼气计算机体层摄影(CT)扫描，测量了肺气肿和小气道疾病。PRMSAD和PRMEMPH以肺面积百分比表示。采用标准化方法测量临床、肺活量和运动能力数据。用多元线性回归分析评价有无BE的受试者的PRMSAD和PRMEMPH的差异，并用广义线性模型分析它们与FEV1和6MWT的关系。在1184名受试者中，有383名(32%)有放射BE。在调整后的模型中，接受放射BE的受试者的PRMEMPH高于未接受放射BE的受试者，但PRMSAD不高于PRMEMPH。在调整后的模型中，有放射BE和PRMEMPH的受试者(在配对CT上定义为≥5%)的FEV1(最小二乘均值，1479mLvs.2350mLP<；0.0001)和6MWT(372mvs.426mP=0.0007)低于单纯放射线BE的受试者。患有BE的吸烟者在配对CT上的肺气肿负担增加，而那些患有BE和肺气肿的吸烟者的气流和运动能力较低。
Bronchiectasis (BE) is associated with COPD, but emphysema and small airways disease, main pathologic features of COPD, have been sparsely studied in BE. We aimed to objectively assess those features in smokers with and without radiographic BE and examine its relationships to airflow obstruction and exercise capacity. We measured emphysema and small airways disease on paired inspiratory-expiratory computed tomography (CT) scans with the parametric response map (PRMEMPH and PRMSAD) method in 1,184 smokers with and without radiographic BE. PRMSAD and PRMEMPH are expressed as the percentage of lung area. Clinical, spirometry, and exercise capacity data were measured with standardized methods. The differences in PRMSAD and PRMEMPH between subjects with and without radiographic BE were assessed using multivariable linear regression analysis, and their associations with FEV1 and six-minute walk test (6MWT) were assessed with generalized linear models. Out of 1,184 subjects, 383 (32%) had radiographic BE. PRMEMPH but not PRMSAD was higher in subjects with radiographic BE than those without radiographic BE in adjusted models. Subjects with radiographic BE and PRMEMPH (defined as ≥5% on paired CTs) had lower FEV1 (least square mean, 1479 mL vs. 2350 mL P<0.0001) and 6MWT (372 m vs. 426 m P=0.0007) than those with radiographic BE alone in adjusted models. Smokers with radiographic BE have an increased burden of emphysema on paired CTs, and those with radiographic BE and emphysema have lower airflow and exercise capacity.
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DOI：
10.2147/copd.s163243
发表时间：
2018
影响因子：
2.8
作者：
Dou S;Zheng C;Cui L;Xie M;Wang W;Tian H;Li K;Liu K;Tian X;Wang X;Zhang Q;Ai X;Che J;Liu Q;Li H;Xiao W
通讯作者：
Xiao W
影响因子：
5
作者：
Matsuoka, Shin;Kurihara, Yasuyuki;Nakajima, Yasuo
通讯作者：
Nakajima, Yasuo
影响因子：
9.6
作者：
McShane, Pamela J.;Tino, Gregory
通讯作者：
Tino, Gregory
影响因子：
9.6
作者：
Diaz, Alejandro A.;Young, Thomas P.;Estepar, Raul San Jose
通讯作者：
Estepar, Raul San Jose
影响因子：
2.6
作者：
Maselli DJ;Amalakuhan B;Keyt H;Diaz AA
通讯作者：
Diaz AA