A Review of Ocular Drug Delivery Platforms and Drugs for Infectious and Noninfectious Uveitis: The Past, Present, and Future.

A Review of Ocular Drug Delivery Platforms and Drugs for Infectious and Noninfectious Uveitis: The Past, Present, and Future.
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DOI:
10.3390/pharmaceutics13081224
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发表时间:
2021-08-08
期刊:
影响因子:
5.4
通讯作者:
Yeh S
Yeh S
中科院分区:
医学2区
文献类型:
--
作者:
Conrady CD;Yeh S

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葡萄膜炎指的是一组广泛的眼部炎症性疾病,通常需要内科和外科治疗来改善或稳定视力,并防止眼睛出现威胁视力的病变。将药物输送到眼睛以对抗炎症和葡萄膜条件下的后续并发症是复杂的,因为存在多个吸收障碍,限制了所需药物在受影响组织中的可获得性。因此,人们对开发新药和药物输送平台以帮助减少眼内炎症及其并发症一直很感兴趣。在这篇综述中,我们讨论了药物输送的挑战,最近批准用于葡萄膜炎患者护理的新技术,以及有前景的葡萄膜炎和眼部炎症后遗症的药物输送平台。
Uveitis refers to a broad group of inflammatory disorders of the eye that often require medical and surgical management to improve or stabilize vision and prevent vision-threatening pathological changes to the eye. Drug delivery to the eye to combat inflammation and subsequent complications from uveitic conditions is complex as there are multiple barriers to absorption limiting availability of the needed drug in the affected tissues. As such, there has been substantial interest in developing new drugs and drug delivery platforms to help reduce intraocular inflammation and its complications. In this review, we discuss the challenges of drug delivery, novel technologies recently approved for uveitis patient care and promising drug delivery platforms for uveitis and sequelae of ocular inflammation.
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