The Role and Modulation of Spinal Perineuronal Nets in the Healthy and Injured Spinal Cord.
The Role and Modulation of Spinal Perineuronal Nets in the Healthy and Injured Spinal Cord.
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DOI：
10.3389/fncel.2022.893857
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发表时间：
2022
影响因子：
5.3
通讯作者：
中科院分区：
文献类型：
--
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而不是一个稳定的支架，神经周围网络（PNNs）是一个动态的和特殊的细胞外基质参与可塑性调节。它们在大脑中被广泛研究，并与神经保护、离子缓冲和神经成熟有关。然而，它们在脊髓中的生物学功能和破坏脊髓PNNs的影响仍然难以捉摸。这篇综述的目的是总结目前关于脊髓PNNs的知识及其在创伤性脊髓损伤（SCI）等病理条件下的潜力。我们还强调了用于调节脊髓损伤后细胞外基质的干预措施，分别针对胶质瘢痕和脊髓pnn，以促进脊髓回路的再生和稳定。这些概念在pnn发育和神经可塑性变化的框架下进行了讨论，得出了脊髓损伤后未成熟神经元和失神经神经元之间的相似性，这可能为未来的脊髓损伤研究提供有用的背景。
Rather than being a stable scaffold, perineuronal nets (PNNs) are a dynamic and specialized extracellular matrix involved in plasticity modulation. They have been extensively studied in the brain and associated with neuroprotection, ionic buffering, and neural maturation. However, their biological function in the spinal cord and the effects of disrupting spinal PNNs remain elusive. The goal of this review is to summarize the current knowledge of spinal PNNs and their potential in pathological conditions such as traumatic spinal cord injury (SCI). We also highlighted interventions that have been used to modulate the extracellular matrix after SCI, targeting the glial scar and spinal PNNs, in an effort to promote regeneration and stabilization of the spinal circuits, respectively. These concepts are discussed in the framework of developmental and neuroplastic changes in PNNs, drawing similarities between immature and denervated neurons after an SCI, which may provide a useful context for future SCI research.
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