Statistical mapping of ictal high-frequency oscillations in epileptic spasms.
Statistical mapping of ictal high-frequency oscillations in epileptic spasms.
复制标题
DOI：
10.1111/j.1528-1167.2010.02786.x
复制
发表时间：
2011-01
期刊：
影响因子：
5.6
通讯作者：
Asano E
中科院分区：
文献类型：
--
作者：
Nariai H;Nagasawa T;Juhász C;Sood S;Chugani HT;Asano E
我们评估了11名儿童中的636例癫痫痉挛（中位数：每名儿童44例痉挛），并确定了与痉挛发作相关的发作期高频振荡（HFO）的空间和时间特征。皮质电图（ECoG）信号从每个孩子的104到148个皮质部位取样，并在每个人的三维MR图像表面上动画显示发作HFO的动态变化。发作ECoG记录的视觉评估显示，每个痉挛事件的特征是HFO增加。时频分析表明，80- 200 Hz的HFO的发作增强最显著，通常先于210- 300 Hz和70 Hz及更慢的HFO。在临床发作之前，罗兰皮质中HFO的募集客观地表现为肌电偏转。发作性运动症状的存在或不存在与Rolandic皮质中的HFO的振幅比癫痫发作区中的HFO的振幅更相关。在很大比例的癫痫痉挛，癫痫发作终止开始在发作区和周围地区的传播，我们称之为“发作甜甜圈现象”的观察。单因素分析表明，完全切除发作期HFO最早增大的部位与良好的手术结局相关。在Rolandic区以80- 200 Hz募集HFO可能在确定癫痫痉挛的发作符号学中起作用。我们使用宏电极的研究表明，80- 200 Hz的发作HFO先于210- 300 Hz。
We assessed 636 epileptic spasms seen in 11 children (median: 44 spasms per child) and determined the spatial and temporal characteristics of ictal high-frequency oscillations (HFOs) in relation to the onset of spasms. Electrocorticography (ECoG) signals were sampled from 104 to 148 cortical sites per child, and the dynamic changes of ictal HFOs were animated on each individual's three-dimensional MR image surface. Visual assessment of ictal ECoG recordings revealed that each spasm event was characterized by augmentation of HFOs. Time-frequency analysis demonstrated that ictal augmentation of HFOs at 80–200Hz was most prominent and generally preceded those at 210–300Hz and at 70Hz and slower. Recruitment of HFOs in the Rolandic cortex preceded the clinical onset objectively visualized as electromyographic deflection. The presence or absence of ictal motor symptoms was related more to the amplitude of HFOs in the Rolandic cortex than in the seizure onset zone. In a substantial proportion of epileptic spasms, seizure termination began at the seizure onset zone and propagated to the surrounding areas; we referred to this observation as the “ictal doughnut phenomenon”. Univariate analysis suggested that complete resection of the sites showing the earliest augmentation of ictal HFOs was associated with a good surgical outcome. Recruitment of HFOs at 80–200Hz in the Rolandic area may play a role in determining seizure semiology in epileptic spasms. Our study using macro-electrodes demonstrated that ictal HFOs at 80–200Hz preceded those at 210–300Hz.
登录
查看更多内容
影响因子：
5.6
作者：
Bisulli, F;Volpi, L;Tassinari, CA
通讯作者：
Tassinari, CA
影响因子：
5.6
作者：
FUSCO, L;VIGEVANO, F
通讯作者：
VIGEVANO, F
DOI：
10.1016/0013-4694(93)90020-v
发表时间：
1993-10-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
GOTMAN, J;LEVTOVA, V;FARINE, B
通讯作者：
FARINE, B
影响因子：
--
作者：
Carlen, PL;Skinner, F;Velazquez, JLP
通讯作者：
Velazquez, JLP
影响因子：
5.7
作者：
Fukuda, Miho;Rothermel, Robert;Juhasz, Csaba;Nishida, Masaaki;Sood, Sandeep;Asano, Eishi
通讯作者：
Asano, Eishi