Electroacupuncture activates inhibitory neural circuits in the somatosensory cortex to relieve neuropathic pain.
Electroacupuncture activates inhibitory neural circuits in the somatosensory cortex to relieve neuropathic pain.
复制标题
电针激活躯体感觉皮层中的抑制神经回路，以减轻神经病理性疼痛。
DOI：
10.1016/j.isci.2021.102066
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发表时间：
2021-02-19
期刊：
影响因子：
5.8
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Wei JA;Hu X;Zhang B;Liu L;Chen K;So KF;Li M;Zhang L
电针已被公认为能有效缓解神经病理性疼痛。目前对其神经调控的认识主要集中在脊髓和皮质下核团，皮质区域的研究很少。在慢性挤压损伤小鼠的体内双光子成像中，我们发现电针治疗可系统地调节初级躯体感觉皮层神经回路的钙活动，包括抑制兴奋性锥体神经元，增强GABA能生长抑素阳性中间神经元，以及抑制血管活性肠肽阳性中间神经元。此外，电针介导的疼痛超敏和皮层调节依赖于内源性大麻素受体1的激活。这些发现共同揭示了在神经病理性疼痛下参与缓解机械或热过敏的大脑皮层回路，并发现了一条指导电针镇痛作用的分子通路。电针减轻神经病理性疼痛的机械超敏反应电针通过调节抑制回路恢复感觉皮层正常的兴奋性-抑制性传递内源性大麻素通路光学成像；行为神经科学；细胞神经科学；转录学
Electroacupuncture (EA) has been accepted to effectively relieve neuropathic pain. Current knowledge of its neural modulation mainly covers the spinal cord and subcortical nuclei, with little evidence from the cortical regions. Using in vivo two-photon imaging in mice with chronic constriction injury, we found that EA treatment systemically modulated the Ca2+ activity of neural circuits in the primary somatosensory cortex, including the suppression of excitatory pyramidal neurons, potentiation of GABAergic somatostatin-positive interneurons, and suppression of vasoactive intestinal peptide-positive interneurons. Furthermore, EA-mediated alleviation of pain hypersensitivity and cortical modulation were dependent on the activation of endocannabinoid receptor 1. These findings collectively reveal a cortical circuit involved in relieving mechanical or thermal hypersensitivity under neuropathic pain and identify one molecular pathway directing analgesic effects of EA. Electroacupuncture (EA) relieves mechanical hypersensitivity in neuropathic pain EA restores normal excitatory-inhibitory transmission in sensory cortex Endocannabinoid pathway underlies EA's effects via modulating inhibitory circuits Optical imaging; behavioral neuroscience; cellular neuroscience; transcriptomics
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影响因子：
7.4
作者：
Kim HY;Wang J;Lee I;Kim HK;Chung K;Chung JM
通讯作者：
Chung JM
影响因子：
7.4
作者：
MacPherson H;Vertosick EA;Foster NE;Lewith G;Linde K;Sherman KJ;Witt CM;Vickers AJ;Acupuncture Trialists' Collaboration
通讯作者：
Acupuncture Trialists' Collaboration
影响因子：
2.9
作者：
Guo, ZL;Moazzami, AR;Longhurst, JC
通讯作者：
Longhurst, JC
DOI：
10.1073/pnas.96.14.7705
发表时间：
1999-07-06
影响因子：
11.1
作者：
Bushnell, MC;Duncan, GH;Carrier, B
通讯作者：
Carrier, B
影响因子：
7.4
作者：
Flatters, SJL;Bennett, GJ
通讯作者：
Bennett, GJ