Biomechanical considerations in the pathogenesis of osteoarthritis of the knee.

Biomechanical considerations in the pathogenesis of osteoarthritis of the knee.
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DOI:
10.1007/s00167-011-1818-0
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发表时间:
2012-03
影响因子:
3.8
通讯作者:
Van Dijk, C. Niek
Van Dijk, C. Niek
中科院分区:
医学2区
文献类型:
--
作者:
Heijink, Andras;Gomoll, Andreas H.;Madry, Henning;Drobnic, Matej;Filardo, Giuseppe;Espregueira-Mendes, Joao;Van Dijk, C. Niek

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骨关节炎是最常见的关节疾病和残疾的主要原因。膝关节是最受影响的大关节。虽然实际年龄是骨关节炎最重要的单一风险因素,但年轻患者膝关节骨关节炎的发病机制主要与关节处不利的生物力学环境相关。这导致机械需求超过关节修复和维持自身的能力,使关节软骨易于过早退化。本文综述了现有的基础科学、临床前和临床证据,这些证据涉及膝关节的几种不利的生物力学条件:对线不良、关节组织丢失、软骨缺损和关节不稳定或松弛。 证据等级IV。
Osteoarthritis is the most common joint disease and a major cause of disability. The knee is the large joint most affected. While chronological age is the single most important risk factor of osteoarthritis, the pathogenesis of knee osteoarthritis in the young patient is predominantly related to an unfavorable biomechanical environment at the joint. This results in mechanical demand that exceeds the ability of a joint to repair and maintain itself, predisposing the articular cartilage to premature degeneration. This review examines the available basic science, preclinical and clinical evidence regarding several such unfavorable biomechanical conditions about the knee: malalignment, loss of meniscal tissue, cartilage defects and joint instability or laxity. Level of evidence IV.
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