Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.
Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.
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DOI：
10.1002/dvdy.22640
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Little MH
中科院分区：
文献类型：
--
作者：
Georgas KM;Chiu HS;Lesieur E;Rumballe BA;Little MH
后肾是成年蝾螈的功能器官，中肾退化。然而，在中肾和后肾之间存在平行的小管发生事件。中肾小管保留在雄性体内，并分化为雄性生殖道的输出管。通过研究小鼠中肾表达的标记物的不同阶段和地区的后肾肾单位在肾小管形成和图案，我们提供了进一步的证据来支持这种常见的形态发生机制。中肾小管表达肾小泡、早期近曲小管、早期远曲小管、Henle袢和肾小体基因。Vip、Slc 6a 20 b和Slc 18 a1是雄性特异性的。相比之下，GUDMAP数据库的挖掘确定了候选的晚期中肾特异性基因，其中10个仅限于男性。在男性特异性基因中，有用于调节传出导管内离子/液体平衡的候选基因，从而调节精子成熟和标记小管相关神经元的基因，这些神经元对正常男性生殖道功能可能至关重要。
The metanephros is the functional organ in adult amniotes while the mesonephros degenerates. However, parallel tubulogenetic events are thought to exist between mesonephros and metanephros. Mesonephric tubules are retained in males and differentiate into efferent ducts of the male reproductive tract. By examining the murine mesonephric expression of markers of distinct stages and regions of metanephric nephrons during tubule formation and patterning, we provide further evidence to support this common morphogenetic mechanism. Renal vesicle, early proximal and distal tubule, loop of Henle and renal corpuscle genes were expressed by mesonephric tubules. Vip, Slc6a20b and Slc18a1 were male-specific. In contrast, mining of the GUDMAP database identified candidate late mesonephros-specific genes, 10 of which were restricted to the male. Amongst the male-specific genes are candidates for regulating ion/fluid balance within the efferent ducts, thereby regulating sperm maturation and genes marking tubule-associated neurons potentially critical for normal male reproductive tract function.
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影响因子：
11.8
作者：
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通讯作者：
McMahon, AP
影响因子：
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作者：
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通讯作者：
Nishimori, Katsuhiko
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
4.5
作者：
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通讯作者：
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