The Secret Life of Exosomes: What Bees Can Teach Us About Next-Generation Therapeutics.
The Secret Life of Exosomes: What Bees Can Teach Us About Next-Generation Therapeutics.
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DOI：
10.1016/j.jacc.2017.11.013
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发表时间：
2018-01-16
影响因子：
24
通讯作者：
Marbán E
中科院分区：
文献类型：
--
作者：
Marbán E
机制探索已经确定了纳米尺寸的细胞外囊泡，称为外泌体，作为细胞治疗益处的关键介质。外泌体似乎概括了细胞的好处，等等。作为持久的无氮实体，外泌体相对于细胞具有许多实际和概念上的优势。细胞最终会被用来制造外泌体，还是会作为主要治疗药物找到持久的价值？在这里，一个受人尊敬的自然过程蜂蜜的产生是一个有启发性的寓言。花制造花蜜，蜜蜂收集花蜜并加工成蜂蜜。细胞制造条件培养基，实验室工作人员收集并加工成外泌体。与鲜花不同，蜂蜜耐用、紧凑、营养丰富，但这些事实并不能否定鲜花本身的价值。这些相似之处为下一代治疗提供了新的思路。
Mechanistic exploration has pinpointed nanosized extracellular vesicles, known as exosomes, as key mediators of the benefits of cell therapy. Exosomes appear to recapitulate the benefits of cells, and more. As durable azoic entities, exosomes have numerous practical and conceptual advantages over cells. Will cells end up just being used to manufacture exosomes, or will they find lasting value as primary therapeutic agents? Here, a venerable natural process—the generation of honey—serves as an instructive parable. Flowers make nectar, which bees collect and process into honey. Cells make conditioned media, which laboratory workers collect and process into exosomes. Unlike flowers, honey is durable, compact and nutritious, but these facts do not negate the value of flowers themselves. The parallels suggest new ways of thinking about next-generation therapeutics.
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影响因子：
21.3
作者：
Hergenreider, Eduard;Heydt, Susanne;Dimmeler, Stefanie
通讯作者：
Dimmeler, Stefanie
影响因子：
13.6
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影响因子：
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Yip HK