Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family.
Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family.
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DOI：
10.1080/19490976.2020.1862612
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发表时间：
2021-01
期刊：
影响因子：
12.2
通讯作者：
Zhu L
中科院分区：
文献类型：
--
作者：
Du J;Zhang P;Luo J;Shen L;Zhang S;Gu H;He J;Wang L;Zhao X;Gan M;Yang L;Niu L;Zhao Y;Tang Q;Tang G;Jiang D;Jiang Y;Li M;Jiang A;Jin L;Ma J;Shuai S;Bai L;Wang J;Zeng B;Wu D;Li X;Zhu L
甜菜碱是一种天然化合物，存在于通常消费的食物中，并且可能在调节葡萄糖和脂质代谢中具有潜在作用。然而，其作用的潜在分子机制在很大程度上仍然未知。在这里，我们表明，补充甜菜碱有助于改善高脂饮食（HFD）诱导的肠道微生物群生态失调，并增加抗肥胖菌株，如嗜粘蛋白阿克曼氏菌（Akkermansia muciniphila），乳酸杆菌（Lactobacillus）和双歧杆菌（Bifidobacterium）。在缺乏肠道微生物群的小鼠中，甜菜碱在预防HFD诱导的肥胖、代谢综合征和棕色脂肪组织失活中的功能作用显著降低。嗜粘蛋白阿克曼氏菌是甜菜碱在改善微生物生态和增加产生短链脂肪酸（SCFA）的菌株中的重要调节剂。增加SCFA的两个主要成员（包括醋酸盐和丁酸盐）可以显着调节宿主miR-378 a启动子的DNA甲基化水平，从而预防肥胖和葡萄糖耐受不良的发生。然而，这些有益的作用被阴阳（YY 1）部分消除，阴阳是miR-378 a家族的共同靶基因。总之，我们的研究结果表明，甜菜碱可以通过肠道微生物群来源的miR-378 a/YY 1调节轴改善肥胖和相关的MS，并揭示了肠道微生物群改善宿主健康的新机制。
Betaine is a natural compound present in commonly consumed foods and may have a potential role in the regulation of glucose and lipids metabolism. However, the underlying molecular mechanism of its action remains largely unknown. Here, we show that supplementation with betaine contributes to improved high-fat diet (HFD)-induced gut microbiota dysbiosis and increases anti-obesity strains such as Akkermansia muciniphila, Lactobacillus, and Bifidobacterium. In mice lacking gut microbiota, the functional role of betaine in preventing HFD-induced obesity, metabolic syndrome, and inactivation of brown adipose tissues are significantly reduced. Akkermansia muciniphila is an important regulator of betaine in improving microbiome ecology and increasing strains that produce short-chain fatty acids (SCFAs). Increasing two main members of SCFAs including acetate and butyrate can significantly regulate the levels of DNA methylation at host miR-378a promoter, thus preventing the development of obesity and glucose intolerance. However, these beneficial effects are partially abolished by Yin yang (YY1), a common target gene of the miR-378a family. Taken together, our findings demonstrate that betaine can improve obesity and associated MS via the gut microbiota-derived miR-378a/YY1 regulatory axis, and reveal a novel mechanism by which gut microbiota improve host health.
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影响因子：
15.9
作者：
Kahn, BB;Flier, JS
通讯作者：
Flier, JS
中国成年人血清中甜菜碱浓度高于胆碱，与 DXA 衍生的身体脂肪和脂肪分布状况更好相关
影响因子：
4.9
作者：
Chen, Y-m;Liu, Y.;Zhu, H-l
通讯作者：
Zhu, H-l
影响因子：
6.5
作者：
Key, Chia-Chi C.;Bishop, Andrew C.;Parks, John S.
通讯作者：
Parks, John S.
影响因子：
82.9
作者：
Depommier, Clara;Everard, Amandine;Cani, Patrice D.
通讯作者：
Cani, Patrice D.
DOI：
10.1073/pnas.1219451110
发表时间：
2013-05-28
影响因子：
11.1
作者：
Everard, Amandine;Belzer, Clara;Cani, Patrice D.
通讯作者：
Cani, Patrice D.