Current Advancements in Sactipeptide Natural Products.
Current Advancements in Sactipeptide Natural Products.
复制标题
当前的乙酰肽天然产品的进步。
DOI：
10.3389/fchem.2021.595991
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发表时间：
2021
影响因子：
5.5
通讯作者：
Ding W
中科院分区：
文献类型：
--
作者：
Chen Y;Wang J;Li G;Yang Y;Ding W
核糖体合成和翻译后修饰多肽(Ripps)是一类日益增长的天然产物，在过去的二十年里受益于基因组测序技术。RIPPs广泛分布于自然界，具有丰富的化学结构和丰富的生物活性。尽管RIPPS具有不同的结构特征，但它们遵循一个共同的生物合成逻辑：由N端前导肽和C端核心肽组成的前体肽；在某些情况下，核心肽之后还有跟随肽。前体多肽经过一系列修饰、运输和裂解步骤，形成具有特定活性的成熟天然产物。硫代-α-碳硫醚交联肽是一类具有抗菌、杀精、溶血等多种生物活性的活性多肽。它们的共同特征是分子内的硫醚键，它将半胱氨酸残基的硫原子与受体氨基酸的α-碳相连，后者由rSAM酶催化。本文综述了近年来有关活性多肽的发现、分布、结构阐明、生物合成及应用前景的研究进展。
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing class of natural products that benefited from genome sequencing technology in the past two decades. RiPPs are widely distributed in nature and show diverse chemical structures and rich biological activities. Despite the various structural characteristic of RiPPs, they follow a common biosynthetic logic: a precursor peptide containing an N-terminal leader peptide and a C-terminal core peptide; in some cases,a follower peptide is after the core peptide. The precursor peptide undergoes a series of modification, transport, and cleavage steps to form a mature natural product with specific activities. Sactipeptides (Sulfur-to-alpha carbon thioether cross-linked peptides) belong to RiPPs that show various biological activities such as antibacterial, spermicidal and hemolytic properties. Their common hallmark is an intramolecular thioether bond that crosslinks the sulfur atom of a cysteine residue to the α-carbon of an acceptor amino acid, which is catalyzed by a rSAM enzyme. This review summarizes recent achievements concerning the discovery, distribution, structural elucidation, biosynthesis and application prospects of sactipeptides.
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影响因子：
5.5
作者：
Benjdia A;Balty C;Berteau O
通讯作者：
Berteau O
DOI：
10.1016/j.bbapap.2011.11.007
发表时间：
2012-11
影响因子：
3.2
作者：
Atta, Mohamed;Arragain, Simon;Fontecave, Marc;Mulliez, Etienne;Hunt, John F.;Luff, Jon D.;Forouhar, Farhad
通讯作者：
Forouhar, Farhad
SKFB在SKFA上从Cα上提取氢原子，以启动硫醚交联的形成。
影响因子：
2.9
作者：
Bruender NA;Bandarian V
通讯作者：
Bandarian V
DOI：
10.1074/jbc.ra120.015371
发表时间：
2020-12-04
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Balty C;Guillot A;Fradale L;Brewee C;Lefranc B;Herrero C;Sandström C;Leprince J;Berteau O;Benjdia A
通讯作者：
Benjdia A
影响因子：
14.8
作者：
Fluehe, Eif;Knappe, Thomas A.;Marahiel, Mohamed A.
通讯作者：
Marahiel, Mohamed A.