Oxytocin and dendrite remodeling in the hypothalamus.
Oxytocin and dendrite remodeling in the hypothalamus.
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DOI：
10.1016/j.yhbeh.2012.01.012
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发表时间：
2012-03
影响因子：
3.5
通讯作者：
Flanagan-Cato, Loretta M.
中科院分区：
文献类型：
--
作者：
Ferri, Sarah L.;Flanagan-Cato, Loretta M.
关键词：
对大多数人来说，他们的生活质量取决于他们与他人的成功相互依赖，这需要复杂的社会认知，沟通和情感纽带。在整个生命周期中，必须建立和维持新的纽带，必须管理同种的威胁。人类社会景观的动态本质表明，多个大脑系统的神经回路正在发生特定的改变，以促进社会行为。为了发现有助于正常社会活动的生物学机制，已经开发了社会行为的动物模型。一个有价值的模型系统是雌性大鼠的性行为，这是由卵巢激素的周期性变化。这种行为是由神经肽催产素（OT）通过其在下丘脑腹内侧核（VMH）中的作用来调节的。这种行为的波动与树突重塑有关，就像行为可塑性的其他几个例子一样。这篇评论比较的VMH与其他的例子树突可塑性在哺乳动物神经系统，即环境富集，慢性应激和激励敏化，影响新皮层，海马结构和腹侧纹状体的神经行为范式的可塑性。这种比较表明，卵巢激素对大鼠VMH神经元的影响，由于简单的树突乔木和树突重塑的短时间过程，为机制和功能研究提供了双重机会，这将揭示i）OT调节社会行为的神经作用，ii）各种脑结构中与行为相关的树突调节。
For most people, their quality of life depends on their successful interdependence with others, which requires sophisticated social cognition, communication, and emotional bonds. Across the lifespan, new bonds must be forged and maintained, and conspecific menaces must be managed. The dynamic nature of the human social landscape suggests ongoing specific alterations in neural circuitry across several brain systems to subserve social behavior. To discover the biological mechanisms that contribute to normal social activities, animal models of social behavior have been developed. One valuable model system has been female rat sexual behavior, which is governed by cyclic variation of ovarian hormones. This behavior is modulated by the neuropeptide oxytocin (OT) through its actions in the hypothalamic ventromedial nucleus (VMH). The fluctuation of this behavior is associated with dendrite remodeling, like several other examples of behavioral plasticity. This review compares hormone-induced plasticity in the VMH with other examples of dendrite plasticity across the mammalian nervous system, namely the neurobehavioral paradigms of environmental enrichment, chronic stress, and incentive sensitization, which affect the neocortex, hippocampal formation, and ventral striatum, respectively. This comparison suggests that the effects of ovarian hormones on VMH neurons in rats, given the simple dendritic arbor and short time course for dendrite remodeling, provides an dual opportunity for mechanistic and functional studies that will shed light on i) the neural actions of OT that regulate social behavior and, ii) behaviorally relevant dendrite regulation in a variety of brain structures.
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DOI：
10.1523/jneurosci.0759-10.2010
发表时间：
2010-05-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bloss EB;Janssen WG;McEwen BS;Morrison JH
通讯作者：
Morrison JH
影响因子：
2.5
作者：
Griffin, Gerald D.;Ferri-Kolwicz, Sarah L.;Reyes, Beverly A. S.;Van Bockstaele, Elisabeth J.;Flanagan-Cato, Loretta M.
通讯作者：
Flanagan-Cato, Loretta M.
影响因子：
4.1
作者：
DEKLOET, ER;VOORHUIS, DAM;ELANDS, J
通讯作者：
ELANDS, J
影响因子：
16.2
作者：
Gaudillière, B;Konishi, Y;Bonni, A
通讯作者：
Bonni, A
影响因子：
3.6
作者：
Georgescu, M;Pfaus, JG
通讯作者：
Pfaus, JG