Assessment of attenuation correction for myocardial PET imaging using combined PET/MRI.
Assessment of attenuation correction for myocardial PET imaging using combined PET/MRI.
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DOI：
10.1007/s12350-017-1118-2
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发表时间：
2019-08
期刊：
影响因子：
--
通讯作者：
Beyer T
中科院分区：
文献类型：
--
作者：
Lassen ML;Rasul S;Beitzke D;Stelzmüller ME;Cal-Gonzalez J;Hacker M;Beyer T
目的：在一组连续接受PET/MR联合成像的心力衰竭患者中，评估基于MR的衰减校正(AC)图中伪影的频率及其对基于PET的血流和代谢测量的定量准确性的影响。20例患者采用双示踪法进行心肌活性研究，包括心肌灌注(13N-NH3：813±8.86 mBq)和代谢(18F-FDG：335±2.38 mBq)。所有采集均使用完全集成的PET/MR系统进行，每次PET扫描均采用标准狄克逊衰减校正(Dixon-AC)标测。检查所有AC图与发射数据、总肺容量、易感性伪影和组织反转(TI)的空间错位。分别使用刚性联合配准和追溯填充敏感性诱导的间隙来纠正错位和磁敏伪影。AC伪影的效果是通过相对差异测量和临床解释的感知变化来评估的。在18例(90%)患者中，PET发射数据和AC图的平均呼吸错位为(7±14.4)mm。在重测分析中，AC图的肺体积发生了实质性的变化(比值：1.0±0.20，范围：0.8~1.4)。10例(50%)患者观察到易感性伪影，而6例(30%)患者有TI伪影。用伪影AC图重建的PET图像的平均差值为14%±110%。综合伪影效应导致3例(15%)患者出现假阳性结果。在对心脏PET/MRI研究进行AC校正之前，必须仔细检查标准的Dixon-AC图是否有伪影和错位效应，以避免对PET数据中的偏向灌注和代谢读数产生误解。本文的在线版本(10.1007/s12350-0171118-2)包含补充材料，可供授权用户使用。
To evaluate the frequency of artifacts in MR-based attenuation correction (AC) maps and their impact on the quantitative accuracy of PET-based flow and metabolism measurements in a cohort of consecutive heart failure patients undergoing combined PET/MR imaging. Myocardial viability studies were performed in 20 patients following a dual-tracer protocol involving the assessment of myocardial perfusion (13N-NH3: 813 ± 86 MBq) and metabolism (18F-FDG: 335 ± 38 MBq). All acquisitions were performed using a fully-integrated PET/MR system, with standard DIXON-attenuation correction (DIXON-AC) mapping for each PET scan. All AC maps were examined for spatial misalignment with the emission data, total lung volume, susceptibility artifacts, and tissue inversion (TI). Misalignment and susceptibility artifacts were corrected using rigid co-registration and retrospective filling of the susceptibility-induced gaps, respectively. The effects of the AC artifacts were evaluated by relative difference measures and perceived changes in clinical interpretations. Average respiratory misalignment of (7 ± 4) mm of the PET-emission data and the AC maps was observed in 18 (90%) patients. Substantial changes in the lung volumes of the AC maps were observed in the test–retest analysis (ratio: 1.0 ± 0.2, range: 0.8-1.4). Susceptibility artifacts were observed in 10 (50%) patients, while six (30%) patients had TI artifacts. Average differences of 14 ± 10% were observed for PET images reconstructed with the artifactual AC maps. The combined artifact effects caused false-positive findings in three (15%) patients. Standard DIXON-AC maps must be examined carefully for artifacts and misalignment effects prior to AC correction of cardiac PET/MRI studies in order to avoid misinterpretation of biased perfusion and metabolism readings from the PET data. The online version of this article (10.1007/s12350-017-1118-2) contains supplementary material, which is available to authorized users.
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影响因子：
9.3
作者：
Martinez-Moeller, Axel;Souvatzoglou, Michael;Nekolla, Stephan G.
通讯作者：
Nekolla, Stephan G.
影响因子：
3.8
作者：
Hunter, Chad R. R. N.;Klein, Ran;deKemp, Robert A.
通讯作者：
deKemp, Robert A.
影响因子：
9.3
作者：
Di Carli, Marcelo F.;Dorbala, Sharmila;Moore, Stephen C.
通讯作者：
Moore, Stephen C.
影响因子：
24
作者：
Jaarsma, Caroline;Leiner, Tim;Schalla, Simon
通讯作者：
Schalla, Simon
DOI：
10.1007/s00259-007-0607-y
发表时间：
2008-02-01
影响因子：
9.1
作者：
Lautamaeki, Riikka;Brown, Tracy L. Y.;Bengel, Frank M.
通讯作者：
Bengel, Frank M.