Adult neural stem cell dysfunction in the subventricular zone of the lateral ventricle leads to diabetic olfactory defects.
Adult neural stem cell dysfunction in the subventricular zone of the lateral ventricle leads to diabetic olfactory defects.
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侧脑室室下区的成体神经干细胞功能障碍导致糖尿病嗅觉缺陷
DOI：
10.4103/1673-5374.211190
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发表时间：
2017-07
影响因子：
6.1
通讯作者：
Yin J
中科院分区：
文献类型：
--
作者：
Jing YH;Qi CC;Yuan L;Liu XW;Gao LP;Yin J
嗅觉辨别的基础是嗅球的结构可塑性，而嗅球的结构可塑性依赖于室管膜下区新生神经元的迁移和整合。在这项研究中，我们研究了糖尿病大鼠脑室下区神经干细胞状态与嗅觉功能之间的关系。通过股静脉注射链脲佐菌素诱导Sprague-Dawley大鼠1型糖尿病。注射后2个月，糖尿病大鼠嗅觉敏感性降低。同时，糖尿病大鼠室管膜下区BrdU阳性细胞和BrdU+/DCX+双标细胞数量均低于同龄正常大鼠。Western blot结果显示糖尿病大鼠室管膜下区胰岛素受体β、磷酸化糖原合成酶激酶3β和β-连环蛋白表达下调。总之，这些结果表明，糖尿病引起胰岛素缺乏，胰岛素缺乏负调节糖原合成酶激酶3β并增强β-连环蛋白降解，这些变化抑制神经干细胞增殖。此外，这些信号通路影响室管膜下区神经干细胞的增殖和分化。室管膜下区神经干细胞功能障碍导致糖尿病大鼠嗅球结构可塑性下降并损害嗅觉敏感性。
Sensitive smell discrimination is based on structural plasticity of the olfactory bulb, which depends on migration and integration of newborn neurons from the subventricular zone. In this study, we examined the relationship between neural stem cell status in the subventricular zone and olfactory function in rats with diabetes mellitus. Streptozotocin was injected through the femoral vein to induce type 1 diabetes mellitus in Sprague-Dawley rats. Two months after injection, olfactory sensitivity was decreased in diabetic rats. Meanwhile, the number of BrdU-positive and BrdU+/DCX+ double-labeled cells was lower in the subventricular zone of diabetic rats compared with age-matched normal rats. Western blot results revealed downregulated expression of insulin receptor β, phosphorylated glycogen synthase kinase 3β, and β-catenin in the subventricular zone of diabetic rats. Altogether, these results indicate that diabetes mellitus causes insulin deficiency, which negatively regulates glycogen synthase kinase 3β and enhances β-catenin degradation, with these changes inhibiting neural stem cell proliferation. Further, these signaling pathways affect proliferation and differentiation of neural stem cells in the subventricular zone. Dysfunction of subventricular zone neural stem cells causes a decline in olfactory bulb structural plasticity and impairs olfactory sensitivity in diabetic rats.
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糖尿病前和2型糖尿病与中央增殖和神经发生有关。
影响因子：
6.1
作者：
Infante-Garcia C;Ramos-Rodriguez JJ;Garcia-Alloza M
通讯作者：
Garcia-Alloza M
影响因子：
3.7
作者：
Real S;Meo-Evoli N;Espada L;Tauler A
通讯作者：
Tauler A
影响因子：
2.5
作者：
Brown, JP;Couillard-Després, S;Kuhn, HG
通讯作者：
Kuhn, HG
影响因子：
7.8
作者：
Arum O;Boparai RK;Saleh JK;Wang F;Dirks AL;Turner JG;Kopchick JJ;Liu JL;Khardori RK;Bartke A
通讯作者：
Bartke A
DOI：
10.1073/pnas.0907063106
发表时间：
2009-10-20
影响因子：
11.1
作者：
Moreno, Melissa M.;Linster, Christiane;Mandairon, Nathalie
通讯作者：
Mandairon, Nathalie