The importance of caveolin as a target in the prevention and treatment of diabetic cardiomyopathy.
The importance of caveolin as a target in the prevention and treatment of diabetic cardiomyopathy.
复制标题
小窝蛋白作为预防和治疗糖尿病心肌病的目标的重要性。
DOI：
10.3389/fimmu.2022.951381
复制
发表时间：
2022
影响因子：
7.3
通讯作者：
Xia, Zhengyuan
中科院分区：
文献类型：
--
作者：
Xia, Weiyi;Li, Xia;Wu, Qingping;Xu, Aimin;Zhang, Liangqing;Xia, Zhengyuan
The diabetic population has been increasing in the past decades and diabetic cardiomyopathy (DCM), a pathology that is defined by the presence of cardiac remodeling and dysfunction without conventional cardiac risk factors such as hypertension and coronary heart diseases, would eventually lead to fatal heart failure in the absence of effective treatment. Impaired insulin signaling, commonly known as insulin resistance, plays an important role in the development of DCM. A family of integral membrane proteins named caveolins (mainly caveolin-1 and caveolin-3 in the myocardium) and a protein hormone adiponectin (APN) have all been shown to be important for maintaining normal insulin signaling. Abnormalities in caveolins and APN have respectively been demonstrated to cause DCM. This review aims to summarize recent research findings of the roles and mechanisms of caveolins and APN in the development of DCM, and also explore the possible interplay between caveolins and APN.
登录
查看更多内容
影响因子：
3.3
作者：
Chen Z;D S Oliveira S;Zimnicka AM;Jiang Y;Sharma T;Chen S;Lazarov O;Bonini MG;Haus JM;Minshall RD
通讯作者：
Minshall RD
影响因子：
3.7
作者：
Byrne DP;Dart C;Rigden DJ
通讯作者：
Rigden DJ
影响因子：
4
作者：
Brannmark, Cecilia;Kay, Emma, I;Olofsson, Charlotta S.
通讯作者：
Olofsson, Charlotta S.
影响因子：
7.7
作者：
Bir SC;Pattillo CB;Pardue S;Kolluru GK;Shen X;Giordano T;Kevil CG
通讯作者：
Kevil CG
影响因子：
5.6
作者：
Achari AE;Jain SK
通讯作者：
Jain SK