Macrophage activation governs schistosomiasis-induced inflammation and fibrosis.

Macrophage activation governs schistosomiasis-induced inflammation and fibrosis.
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DOI:
10.1002/eji.201141869
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发表时间:
2011-09
影响因子:
5.4
通讯作者:
Wynn, Thomas A.
Wynn, Thomas A.
中科院分区:
医学3区
文献类型:
--
作者:
Barron, Luke;Wynn, Thomas A.

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巨噬细胞调节慢性炎症反应的启动、维持和消退,其功能取决于其激活状态。对感染曼氏血吸虫寄生虫的小鼠的研究特别有助于确定经典和交替激活的巨噬细胞的体内功能(ϕ,S)。这些研究表明,AMϕS通过不同的机制保护小鼠免受曼氏血吸虫的急性和慢性感染,本文对此进行了讨论。
Macrophages regulate the initiation, maintenance, and resolution of chronic inflammatory responses and their function depends on their activation status. Studies in mice infected with the helminth parasite Schistosoma mansoni have been particularly helpful in defining the in vivo function of classically and alternatively activated macrophages (AAMϕs). These studies have shown that AAMϕs protect mice from acute and chronic S. mansoni infection through distinct mechanisms, which are discussed in this Viewpoint.
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