Anti-GAPDH Autoantibody Is Associated with Increased Disease Activity and Intracranial Pressure in Systemic Lupus Erythematosus
Anti-GAPDH Autoantibody Is Associated with Increased Disease Activity and Intracranial Pressure in Systemic Lupus Erythematosus
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抗 GAPDH 自身抗体与系统性红斑狼疮疾病活动度和颅内压升高相关
DOI：
10.1155/2019/7430780
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发表时间：
2019-03
影响因子：
4.1
通讯作者：
Yi Li
中科院分区：
文献类型：
--
作者：
Sun Jingjing;Li Xue;Zhou Haotian;Liu Xiaoyun;Jia Jingjing;Xie Qizhi;Peng Sijia;Sun Xiaolin;Wang Qingwen;Yi Li
目的系统性红斑狼疮(SLE)是一种以多器官受累为特征的免疫性疾病。神经精神性系统性红斑狼疮(NPSLE)是系统性红斑狼疮(SLE)最严重的并发症之一，缺乏有效的诊断生物标志物。最近对抗GAPDH自身抗体的研究表明，它在NPSLE中具有潜在的致病作用。然而，抗GAPDH自身抗体在SLE患者中的临床相关性仍然难以捉摸。本研究旨在检测SLE患者血清中抗GAPDH自身抗体的水平，以探讨抗GAPDH自身抗体在SLE中的临床意义。方法采用酶联免疫吸附试验(EL ISA)检测130例SLE患者和55例健康人血清中3-磷酸甘油醛脱氢酶自身抗体(抗GAPDH自身抗体)水平。在130例SLE患者中，95例为无神经精神症状的SLE患者，35例为NPSLE患者。按实验室常规方法检测白细胞计数、血红蛋白、血小板计数、免疫球蛋白、免疫球蛋白A、免疫球蛋白M、抗双链DNA、补体C3、补体C4、血沉、C反应蛋白、RF、抗心磷脂、抗核抗体、AnuA、抗SSA、抗SSB、β2-GPI、尿常规及24 h尿蛋白。分别对系统性红斑狼疮疾病活动指数(SLEDAI-2K)和系统性红斑狼疮国际协作诊所/美国风湿病学会(SLICC/ACR)损害指数进行评分。结果系统性红斑狼疮患者血清中抗GAPDH自身抗体水平明显升高，尤其是非狼疮性狼疮患者(P=0.0011)。血清抗-GAPDH值与SLEDAI-2K(P=0.017)、血沉、Ig G、Ig M升高相关，与颅内压升高、脑血管病变发生率相关，但对癫痫的发生率有保护作用。结论无论有无神经精神症状，SLE患者血清中抗GAPDH自身抗体均升高，且与病情严重程度相关。它可能成为未来临床实践中脑组织损伤的指标。
Objective Systemic lupus erythematosus (SLE) is an immune disease characterized by multiorgan involvement. Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most devastating complications of SLE, which lacks efficient diagnostic biomarkers. The recent studies on the anti-GAPDH autoantibodies suggested its potential pathogenic roles in NPSLE. However, the clinical relevance of the anti-GAPDH autoantibodies in patients with SLE is still elusive. In this study, we sought to determine the serum levels of the anti-GAPDH autoantibodies in patients with SLE to investigate the clinical significance of the anti-GAPDH autoantibodies in SLE. Methods Concentrations of the glyceraldehyde 3-phosphate dehydrogenase autoantibodies (anti-GAPDH autoantibodies) in the serum of 130 SLE patients and 55 healthy individuals were determined by enzyme-linked immunosorbent assay (ELISA). Among the 130 SLE patients, 95 were SLE patients without neuropsychiatric symptoms and 35 had NPSLE. White blood cell (WBC) count, hemoglobin (HB), platelet count (PLT), IgG, IgA, IgM, anti-dsDNA, C3, C4, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), RF, anti-cardiolipin (Acl), ANA, AnuA, anti-SSA, anti-SSB, β2-GPI, urinalysis, and 24 h urine protein were measured by standard laboratory techniques. Systemic lupus erythematosus disease activity index 2000 (SLEDAI-2K) and Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index scores were evaluated accordingly. Results The serum levels of the anti-GAPDH autoantibodies were significantly elevated in the SLE patients, especially in the patients with NPSLE (P = 0.0011). Elevated serum anti-GAPDH was correlated with increased SLEDAI-2K (P = 0.017), ESR, IgG, and IgM and associated with increased intracranial pressure and incidence of cerebrovascular lesions, but it was protective for seizure disorder incidence. Conclusions Serum anti-GAPDH autoantibody was increased in both groups of SLE patients with or without neuropsychiatric symptoms and associated with disease severity. It could become an indicator of tissue damages in the brain for the future clinical practice.
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影响因子：
--
作者：
Nada Alaaeddine;J. Battista;J. Pelletier;K. Kiansa;Cloutier Jm;J. Martel-Pelletier
通讯作者：
Nada Alaaeddine;J. Battista;J. Pelletier;K. Kiansa;Cloutier Jm;J. Martel-Pelletier
影响因子：
9.3
作者：
Kivity S;Agmon-Levin N;Zandman-Goddard G;Chapman J;Shoenfeld Y
通讯作者：
Shoenfeld Y
DOI：
--
发表时间：
2004-02
期刊：
The Journal of rheumatology
影响因子：
--
作者：
M. Matsushita;Y. Takasaki;K. Takeuchi;Hirofumi Yamada;R. Matsudaira;H. Hashimoto
通讯作者：
M. Matsushita;Y. Takasaki;K. Takeuchi;Hirofumi Yamada;R. Matsudaira;H. Hashimoto
影响因子：
--
作者：
TAN, EM
通讯作者：
TAN, EM
影响因子：
13.6
作者：
Stojanovich, Ljudmila;Zandman-Goddard, Gisele;Sikanich, Natasa
通讯作者：
Sikanich, Natasa