Polymer-based photocoupling agent for the efficient immobilization of nanomaterials and small molecules.
Polymer-based photocoupling agent for the efficient immobilization of nanomaterials and small molecules.
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DOI：
10.1021/la201324h
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发表时间：
2011-08-02
期刊：
影响因子：
--
通讯作者：
Yan M
中科院分区：
文献类型：
--
作者：
Kubo T;Wang X;Tong Q;Yan M
基于全氟叠氮苯（PFPA）-共轭聚烯丙基胺（PAAm）的高效光耦合剂被开发用于聚合物、纳米颗粒、石墨烯和小分子的高效固定。合成了偶联物PAAm-PFPA，并且可以通过合成中两种组分的比例来控制光活性部分PFPA的百分比。通过用PAAm-PFPA处理环氧官能化的晶片，产生光活性表面。与PFPA表面相比，这些基于聚合物的光耦合基质导致显著增强的固定效率，特别是对于纳米材料和小分子。因此，聚苯乙烯纳米粒子（PS NPs）和烷基官能化的二氧化硅纳米粒子（SNPs）成功地固定在PAAm-PFPA表面，导致高的材料密度。与固定在PFPA表面上的那些相比，在PAAm-PFPA表面上图案化的石墨烯薄片除了更高的材料密度之外还显示出改进的特征分辨率。此外，2-O-α-D-吡喃甘露糖基-D-吡喃甘露糖（Man 2）固定在PAAm-PFPA表面表现出显着增强的信号时，与凝集素伴刀豆球蛋白A（Con A）。
A highly efficient photocoupling agent, based on perfluorophenylazide (PFPA)-conjugated polyallylamine (PAAm), was developed for the efficient immobilization of polymers, nanoparticles, graphene, and small molecules. The conjugate, PAAm-PFPA, was synthesized, and the percent of the photoactive moiety, PFPA, can be controlled by the ratio of the two components in the synthesis. By treating epoxy-functionalized wafers with PAAm-PFPA, photoactive surfaces were generated. Compared with the PFPA surface, these polymer-based photocoupling matrix resulted in significantly enhanced immobilization efficiencies, especially for nanomaterials and small molecules. Thus polystyrene nanoparticles (PS NPs) and alkyl-functionalized silica nanoparticles (SNPs) were successfully immobilized on the PAAm-PFPA surface, resulting in high material density. Graphene flakes patterned on the PAAm-PFPA surface showed improved feature resolution in addition to a higher material density compared to those immobilized on the PFPA surface. Furthermore, 2-O-α-D-mannopyranosyl-D-mannopyranose (Man2) immobilized on the PAAm-PFPA surface exhibited significantly enhanced signals when treated with the lectin Concanavalin A (Con A).
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