Divergent quasispecies evolution in de novo hepatitis C virus infection associated with bone marrow transplantation.
Divergent quasispecies evolution in de novo hepatitis C virus infection associated with bone marrow transplantation.
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DOI：
10.1016/j.bbrc.2011.09.041
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发表时间：
2011-10-14
影响因子：
3.1
通讯作者：
Di Bisceglie, Adrian M.
中科院分区：
文献类型：
--
作者：
Wang, Weihua;Lin, Jianguo;Tan, De;Xu, Yanjuan;Brunt, Elizabeth M.;Fan, Xiaofeng;Di Bisceglie, Adrian M.
Quasispecies is a remarkable characteristic of hepatitis C virus (HCV) and has profound roles in HCV biology and clinical practice. The understanding of HCV quasispecies behavior, in particular in acute HCV infection, is valuable for vaccine development and therapeutic interference. However, acute HCV infection is seldom encountered in clinic practice due to its silent onset. In the present study, we reported a unique case of de novo HCV infection associated with the transplantation of bone marrow from a HCV-positive donor. HCV quasispecies diversity was determined in both the donor and the recipient over a 4-year follow-up, accompanied with simultaneous measurement of HCV neutralizing antibody. Detailed genetic and phylogenetic analyses revealed a divergent quasispecies evolution, which was not related to dynamic changes of HCV neutralizing antibody. Instead, our data suggested an essential role of the fitness adaptation of founder viral population in driving such an evolutionary pattern.
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DOI：
10.1084/jem.20090766
发表时间：
2010-08-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Fafi-Kremer S;Fofana I;Soulier E;Carolla P;Meuleman P;Leroux-Roels G;Patel AH;Cosset FL;Pessaux P;Doffoël M;Wolf P;Stoll-Keller F;Baumert TF
通讯作者：
Baumert TF
影响因子：
5.8
作者：
Posada, D;Crandall, KA
通讯作者：
Crandall, KA
影响因子：
6.4
作者：
Herring, BL;Page-Shafer, K;Delwart, EL
通讯作者：
Delwart, EL
影响因子：
29.4
作者：
Lyra, AC;Fan, XF;Di Bisceglie, AM
通讯作者：
Di Bisceglie, AM
影响因子：
158.5
作者：
Alter, MJ;Kruszon-Moran, D;Margolis, HS
通讯作者：
Margolis, HS