Pathology and function of nuclear amyloid. Protein homeostasis matters.
Pathology and function of nuclear amyloid. Protein homeostasis matters.
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DOI：
10.4161/nucl.29404
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发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
von Mikecz A
中科院分区：
文献类型：
--
作者：
von Mikecz A
In aging societies increasing cases of neurodegenerative protein deposit diseases urge for the identification of the underlying mechanisms. Expectations are that in 2050 the percentage of population over age 60 is 42% in Japan, 34% in China, and 27% in the US. The cell nucleus is a major target of amyloid-like protein fibrillation in a variety of disorders that are characterized by widespread aggregation of proteins with instable homopolymeric amino acid repeats, ubiquitin, and other proteinaceous components. Additionally, accumulation of insoluble, SDS-resistant proteins has been identified as an intrinsic property of organismal aging. This review collects current knowledge about the composition and function of insoluble, nuclear protein inclusions from the protein homeostasis perspective. It discusses the occurrence and role of nuclear amyloid in the diseased as well as the healthy cell. Features of nuclear inclusions such as protein composition and locally active protein degradation may predict neural fitness and survival in a variety of health or disease settings.
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影响因子：
5.3
作者：
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通讯作者：
Riess, Olaf
影响因子：
2.5
作者：
Arnhold, Florian;von Mikecz, Anna
通讯作者：
von Mikecz, Anna
影响因子：
4
作者：
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通讯作者：
Nilsson, K. Peter R.
DOI：
10.1016/s0006-291x(02)00498-9
发表时间：
2002-06-07
影响因子：
3.1
作者：
Hazeki, N;Tsukamoto, T;Kanazawa, I
通讯作者：
Kanazawa, I
影响因子：
3.7
作者：
Chen, M;von Mikecz, A
通讯作者：
von Mikecz, A