BMP signaling pathway and spinal cord development

BMP signaling pathway and spinal cord development
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BMP信号通路与脊髓发育

DOI:
10.1007/s11515-011-1178-7
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发表时间:
2012-01
期刊:
Frontiers in Biology
影响因子:
--
通讯作者:
Naihe Jing
Naihe Jing
中科院分区:
其他
文献类型:
--
作者:
Zhihui Xie;Zhihui Xie;Naihe Jing;Naihe Jing

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脊髓的发育是一个精确、顺序调节的过程,受各个阶段信号通路和转录因子的控制。大量的数据表明,BMP信号转导在这一发育过程的不同阶段发挥着重要作用。同样清楚的是,BMP信号传导的适当功能需要其与包括Notch、Wnt和视黄酸(RA)途径的几种其它信号传导途径的串扰。在这里,我们强调了最近的进展,了解BMP信号在神经发生,神经管图案,轴突发育和神经胶质细胞分化在脊髓中的作用,并强调其整合与其他途径在这些过程中。
The development of spinal cord is a precisely and sequentially regulated process, which is controlled by signaling pathways and transcription factors in each stage. Overwhelming data have shown the essential roles of BMP signaling in different stages of this developmental process. It is also clear that the proper functions of BMP signaling require its cross-talk with several other signaling pathways including Notch, Wnt and retinoic acid (RA) pathways. Here, we highlight the recent advancement in understanding the roles of BMP signaling during neurogenesis, neural tube patterning, axon development and glial differentiation in the spinal cord, and emphasize its integrations with other pathways during these processes.
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